US3816253A
Expired / Lapsed
US
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Method for the production of cephalosporins
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1972-03-31
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Granted: 1974-06-11
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Expires: 1992-03-31
Abstract
Abstract WHEREIN R'' has the aforementioned significance through the utilization of a microorganism having a novel type of enzymatic activity. The compounds have strong antibacterial action against gram-positive and gram-negative bacteria. WHEREIN R has the aforementioned significance, or its reactive derivative and (2) a 7-aminocephem compound of the formula WHEREIN R stands for a six-membered cyclic hydrocarbon residue or a five-membered heterocyclic residue and R'' stands for a hydrogen atom or an organic radical the indicated linkage of which is that between the methylene carbon atom and an oxygen, sulfur or nitrogen atom composing the organic radical, are produced by condensation between (1) an Alpha -substitutedAlpha -amino acid of the formula Cephalosporins of the formula
Inventors
- 👤 T Takahashi
- 👤 Y Yamazaki
- 👤 K Kato
- 👤 M Isono
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:16
CPC Classifications
C; C12; C12P; C12P35/00; C12P35/04; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/823; Y10S435/848; Y10S435/874; Y10S435/882
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
36 words
A method according to claim 1, wherein the Alpha -substituted- Alpha -amino acid or reactive derivative thereof and the 7-aminocephem compound are contacted with a culture broth of the microorganism or with enzyme-containing processed material thereof.
Claim 2
Dependent Claim
29 words
A method according to claim 2, wherein the contact is at a temperature from about 5* to about 50*C and at a pH from about 4 to about 8.
Claim 3
Dependent Claim
54 words
A method according to claim 2, wherein the concentration of the 7-aminocephem compound in the aqueous medium is in a range from about 0.1 to about 10 percent (weight/volume) and that of the Alpha -substituted- Alpha -amino acid or its reactive derivative is in a range from about 0.1 to about 20 percent (weight/volume).
Claim 4
Dependent Claim
36 words
A method according to claim 1 wherein the reactive derivative of the carboxylic moiety is an alkyl ester, a thioester, an amide or a dipeptide between the Alpha -substituted- Alpha -amino acid and another amino acid.
Claim 5
Dependent Claim
17 words
A method according to claim 1, wherein the organic radical R'' is alkoxy, alkoxycarbonyl, pyridino or 1-oxidopyrid-2-ylthio.
Claim 6
Dependent Claim
12 words
A method according to claim 1, wherein R'' is a hydrogen atom.
Claim 7
Dependent Claim
10 words
A method according to claim 6, wherein R'' is methoxy.
Claim 8
Dependent Claim
10 words
A method according to claim 6, wherein R'' is methoxycarbonyl.
Claim 9
Dependent Claim
13 words
A method according to claim 1, wherein the five-membered heterocyclic residue is thienyl.
Claim 10
Dependent Claim
19 words
A method according to claim 1, wherein the six-membered cyclic hydrocarbon residue is substituted by hydroxy, halogen or both.
Claim 11
Dependent Claim
10 words
A method according to claim 1, wherein R is phenyl.
Claim 12
Dependent Claim
16 words
A method according to claim 1, wherein R is phenyl substituted by hydroxy, halogen or both.
Claim 13
Dependent Claim
10 words
A method according to claim 1, wherein R is cyclohexenyl.
Claim 14
Dependent Claim
10 words
A method according to claim 1, wherein R is cyclohexyl.
Claim 15
Dependent Claim
19 words
A method according to claim 1, wherein R is cyclohexenyl and R'' is a hydrogen atom, methoxy or methoxycarbonyl.
Claim 16
Dependent Claim
67 words
A method according to claim 1, wherein the microorganism is Mycoplana dimorpha, Mycoplana bullata, Protaminobacter alboflavus, Acetobacter acetosus, Acetobacter albidus, Acetobacter aurantium, Acetobacter cerinus, Acetobacter industrius, Acetobacter dioxyacetonicus, Acetobacter gluconicus, Acetobacter liquefaciens, Acetobacter melanogenus, Acetobacter oxydans, Acetobacter pasteurianus, Acetobacter suboxydans, Acetobacter turbidans, Acetobacter xylinum, Xanthomonas citri, Xanthomonas pruni, Xanthomonas oryzae, Pseudomonas aeruginosa, Pseudomonas maltophila, Pseudomonas melanogenus, Pseudomonas vendrelli, Aeromonas hydrophila, Escherichia coli or Escherichia coli var communior.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-06-10 | 1977-12-10 | 1978-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-06-10 | 1981-12-10 | 1982-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-06-10 | 1985-12-10 | 1986-06-11 | $7700.00 | Window Closed / Lapsed |