Ortho-amino benzoyl hydrazine derivatives and process for preparing the same
Abstract
Abstract NEW ORTHO-AMINO BENZOYL HYDRAZINE DERIVATIVES OF THE GENERAL FORMULA 1: 1-(R2-N(-R3)-NH-CO-),2-(R1-NH-),3-R6,4-R5,5-R4-BENZENE WHEREIN R1, R2, R3, R4, R5 AND R6 ARE SELECTED ORAGNIC GROUPS, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME AS ACTIVE INGREDIENTS, HAVING ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTION. A METHOD OF MANUFACTURING THE HYDRAZINE DERIVATIVES OF FORMULA 1 COMPRISES REACTING A PRIMARY AMINE WITH ORTHO-HALOGENOBENZOIC ACID AT REFLUX IN AN ORGANIC SOLVENT IN THE PRESENCE OF POTASSIUM CARBONATE AND CUPRIC ACETATE, COLLECTING THEORTHO-AMINO BENZOIC ACID DERIVATIVE THUS FORMED, REACTING SAID BENZOIC ACID DERIVATIVES WITH PHOSGENE IN A BASIC ENVIRONMENT TO FORM AN ISATOIC ANHYDRIDE DERIVATIVE WHICH IS COLLECTED AND REACTED WITH HYDRAZINE OR A SUBSTITUTED HYDRAZINE.
Inventors
- 👤 J Philippe
Bibliographic Details
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