6-(lower alkylidene)iminooxycarbonamido)-penicillanic acids and method of their preparation

Abstract

Abstract NOVEL PENICILLANIC ACID AND CEPHALOSPHORANIC ACID DERIVATIVES OF THE FORMULA R''-C(-R2)=N-OOC-NH-R WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF 2-(HOOC-),3,3-DI(CH3-)PENAM-6-YL, 2-(HOOC-),3-(R3-CH2-)-2-CEPHEM-7-YL AND 1,7-DI(O=)-1,4,5A,6-TETRAHYDRO-3H,7H-AZETO(2,1-B)FURO- (3,4-D)-1,3-THIAZIN-6-YL R'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKOXYCARBONYL, LOWER ALKANOYL, ARYL, BENZYL, HETEROCYCLIC OF 5 TO 5 ATOMS IN THE RING AND THE HETERO ATOM IS NITROGEN, OXYGEN OR SULFUR LINKED THROUGH A CARBON ATOM AND A PHENYLMETHYLIDENE-HYDROXYIMINO, R2 IS A SELECTED FROM THE GROUP CONSISTING OF LOWER AKYL, LOWER ALKANOYL AND PHENYL AND R'' AND R2 TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE ATTACHED FROM A CYCLOAKYLIDENE OF 5 TO 8 CARBON ATOMS, R3 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKANOYLOXY AND THE SAID ARYL, BENZYL AND CYCLOALKYLIDENE OPTIONALLY ARE SUBSTITUTED WITH AT LEAST ONE MEMBER OF THE GROUP CONSISTING OF HALOGEN, LOWER ALKYL AND LOWER ALKOXY AND THEIR NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS, ESTERS AND AMIDES AND THEIR PRPEARTION AND THEIR USE AS ANTIBIOTICS.

Inventors

• 👤 P Henniger

Bibliographic Details