Process for the preparation of 5-aryl-2,3-dihydro-2,2(or 3,3)dimethyl-5h-imidazo (2,1-a)isoindol-5-ols and 2(4,4(or 5,5)dimethyl-2-imidazolin-2-yl)benzophenone acid addition salts

Abstract

Abstract NOVEL COMPOUNDS HAVE BEEN PREPARED WHICH HAVE USEFUL PHARMACOLOGICAL ACTIVITY AS WELL AS INTERMEDIATES FOR THEIR PRODUCTION. SOME OF THE PROCESSES HAVE UTILITY FOR THE PRODUCTION OF OTHER PHARMACOLOGICALLY ACTIVE COMPOUNDS THE ACTIVE COMPOUNDS OF THIS INVENTION ARE THOSE OF THE FOLLOWING FORMULAS: 2-(2-(R1-CO-),R2,R3-PHENYL),R4,R5-2-IMIDAZOLINE . HX AND 5-R1,R2,R3,R4,R5-2,3-DIHYDRO-5H-IMIDAZO(2,1-A)ISOINDOL- 5-OL WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF PHENYL, MONOHALIPHENYL, DIHALOPHENYL, MONP(LOWER) ALKYLPHENYL, DI(LOWER)ALKYLPHENYL, TRIFLUOROPMETHYLPHENYL, MONO(LOWER)ALKOXYPHENYL, DI(LOWER)ALKOXYPHENYL, THIENYL, PYRIDYL, FURYL, AND TETRAHYDRO--2-NAPHTHYL, R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN HALOGEN, AMINO, (LOWERALKYLAMINO, (LOWER)ALKYL AND (LOWER)ALKOXY, R3 IS HYDROGEN WHEN R2 AND R3 ARE DISSIMILAR AND WHEN R2 AND R3 ARE THE SAME THEY ARE BOTH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, (LOWER)ALKYL AND (LOWER)ALKOXY; R4 AND R5 ARE LOWER ALKYL AND ATTACHED TO THE SAME CARBON ATOM; X IS THE ANION PORTION OF A PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALT.

Inventors

• 👤 T Sulkowski
• 👤 A Mascitti

Bibliographic Details