Mono-acetyl derivatives of antibiotic sf-837 and sf-837-a2 substances and production thereof
Abstract
Abstract NEW MONO-ACETATES OF ANTIBIOTICS SF-837 SUBSTANCE AND SF-837-A2 SUBSTANCE REPRESENTED BY THE FORMULA 2,9-DI(CH3-),8-(R2-O-),11-(OCH-CH2-),13-(CH3-O-),14- (R1-O-),16-(O=),12-((3-((3-(R4-CH2-CH2-COO-),2,4- (CH3-),4-(HO-)-TETRAHYDROPYRAN-6-YL)-O-),2-(CH3-),4- (CH3-N(-CH3)-),5-(HO-)-TETRAHYDROPYRAN-6-YL)-O-) OXACYCLOHEXADECA-4,6-DIENE WHERE R1 IS PROPIONYL GROUP, R2 IS AN ACETYL GROUP, AND R4 IS HYDROGEN ATOM OR METHYL GROUP, MAY BE PRODUCED BY PARTIALLY HYDROLYZING UNDER NON-ACIDIC CONDITIONS THE DI-ACETATES OF SF-837 SUBSTANCE AND SF-937-A2 SUBSTANCE, RESPECTIVELY, WHICH HAVE BEEN DERIVED BY ACEETYLATING THE SF-837 SUBSTANCE AND SF-837-A2 SUBSTANCE IN THE FORM OF THE FREE BASES AS PREPARED THROUGH THE CULTIVATION OR STREPTOMYCES MYCAROFACIENS IDENTIFIED AS ATCC NO. 21454. THE MONO-ACETATES OF THE SF-837 AND SF-837-A2 SUBSTANCES ARE MUCH MORE EXCELLENT AS THE ANTI-BACTERIAL AGENT THAN THEIR CORRESPONDING FREE BASES ABD DI-ACETATES.
Inventors
- 👤 S Fukatsu
- 👤 T Ishikawa
- 👤 B Nomiya
- 👤 T Koeda
- 👤 T Miuro
- 👤 T Niida
Bibliographic Details
Claims Analysis
Total Claims: 1References Cited (Backward Citations)
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