Method for the preparation of small medicament particles
Abstract
Abstract A METHOD FOR FORMING MEDICATED PARTICLES BY ALTERNATELY APPLYING PORTIONS OF A LIQUID AND OF A SOLID POWDERED MEDICAMENT, INSOLUBLE IN SAID LIQUID, TO AN AGITATED SEED MATERIAL, AND DRYING SAID PARTICLES ONLY AFTER ALL SAID PORTIONS HAVE BEEN APPLIED. IF REQUIRED, A LIQUIDSOLUBLE BINDER FOR SAID MEDICAMENT MAY BE PRESENT, EITHER DISSOLVED IN THE LIQUID OR ADMIXED AS A POWDER WITH THE MEDICAMENT. EACH PORTION OF LIQUID IS WITHIN THE "CRITICAL LIQUID UPTAKE" REGION OF THE POWDER PORTION NEXT APPLIED, SAID REGION BEING EMPIRICALLY DETERMINED FOR EACH SYSTEM OF LIQUID AND MEDICAMENT (AND, IF NECESSARY, BINDER). SAID REGION ENCOMPASSES THOSE MIXTURES OF LIQUID AND SOLID SYSTEM COMPONENTS WHICH HAVE A CONSISTENCY BETWEEN STICKINESS, ON THE ONE HAND, AND A TENDENCY TO CRUMBLE, ON THE OTHER.
Inventors
- 👤 G Rothgang
- 👤 G Simon
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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