US3776241A
Expired / Lapsed
US
⏱️ 0.0 years remaining
System and method for controlling vascular responses
Assignee: Iowa State University Research Foundation Inc
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Filing: 1971-08-13
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Granted: 1973-12-04
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Expires: 1991-08-13
Abstract
Abstract A method and a system are disclosed for producing changes in systemic arterial blood pressure, cerebrospinal fluid pressure and heart rate; as well as producing selective brain hypothermia in animals by irrigating the nasal mucosa.
Inventors
- 👤 J Magilton
- 👤 C Swift
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:46
CPC Classifications
A; A61; A61M; A61M19/00; A61F; A61F7/00; A61F7/12; A61B; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00084
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
120 words
A system for controlling the temperature of the brain of an animal comprising temperature sensitive means sensing the temperature of blood the angularis oculi vein of said animal for generating a signal representative of said temperature; circuit means receiving said signal for generating a signal representative of a difference between the temperature in said angularis oculi vein and a reference temperature; a source of fluid; means for controlling the flow rate of said fluid responsive to said error signal; timing circuit means for inhibiting said control for a predetermined time sufficient for a change in said flow rate to be sensed by said temperature sensitive means; and means for directing said cooled gas against the nasal mucosa of said animal.
Claim 2
Independent Claim
120 words
A system for controlling the temperature of the brain of an animal comprising temperature sensitive means sensing the temperature of blood the angularis oculi vein of said animal for generating a signal representative of said temperature; circuit means receiving said signal for generating a signal representative of a difference between the temperature in said angularis oculi vein and a reference temperature; a source of fluid; means for controlling the flow rate of said fluid responsive to said error signal; timing circuit means for inhibiting said control for a predetermined time sufficient for a change in said flow rate to be sensed by said temperature sensitive means; and means for directing said cooled gas against the nasal mucosa of said animal.
Claim 3
Dependent Claim
20 words
The apparatus of claim 1 wherein said fluid is a gas and further comprising means for humidifying said fluid gas.
Claim 4
Dependent Claim
25 words
The system of claim 1 further comprising means for introducing a local anesthetic into said fluid stream to apply said anesthetic to said nasal mucosa.
Claim 5
Dependent Claim
161 words
Apparatus for controlling the brain temperature of an animal comprising: temperature sensitive means adapted for placement in close proximity to the angularis occuli vein of the animal for generating a signal representative of the temperature of the venous blood in said vein flowing from the nasal mucosa; means including a source of fluid cooled below the normal temperature of said venous blood and adapted to direct said fluid against the nasal mucosa of the animal, said means further including control means for controlling the flow rate of said fluid; circuit means receiving said temperature signal for driving said control means to vary the flow rate of said fluid to effect a desired temperature in said venous blood, said circuit further including means for delaying the driving of said control means in response to a sensed temperature for a period of time between the application of said fluid and sensing of the correspoNding change in temperature sensed by said temperature sensitive means.
Claim 6
Dependent Claim
161 words
Apparatus for controlling the brain temperature of an animal comprising: temperature sensitive means adapted for placement in close proximity to the angularis occuli vein of the animal for generating a signal representative of the temperature of the venous blood in said vein flowing from the nasal mucosa; means including a source of fluid cooled below the normal temperature of said venous blood and adapted to direct said fluid against the nasal mucosa of the animal, said means further including control means for controlling the flow rate of said fluid; circuit means receiving said temperature signal for driving said control means to vary the flow rate of said fluid to effect a desired temperature in said venous blood, said circuit further including means for delaying the driving of said control means in response to a sensed temperature for a period of time between the application of said fluid and sensing of the correspoNding change in temperature sensed by said temperature sensitive means.
Claim 7
Dependent Claim
47 words
The apparatus of claim 4 wherein said fluid is a gas and further comprising means for adding an anesthetic to said gas prior to contacting said nasal mucosa; and means for adding humidity to said gas after cooling the same and prior to contacting said nasal mucosa.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-12-03 | 1977-06-04 | 1977-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-12-03 | 1981-06-04 | 1981-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-12-03 | 1985-06-04 | 1985-12-04 | $7700.00 | Window Closed / Lapsed |