N-protected amino acids and peptides
Abstract
Abstract NOFEL N-PROTECTED AMINO ACIDS REPRESENTED BY THE FORMULA R-C*C-C(-R1)(-R2)-OOC-NH-A WHERE R IS H, CL, PHENYL OR SUBSTITUTED PHENYL; R1 IS H OR C1-C4 ALKYL, R2 IS C1-C4 ALKYL AND A IS THE RESIDUE OF AN AMINO ACID, ARE OBTAINED BY REACTING AN ACETYLENIC CHLORO OR FLUOROFORMATE ESTER OR A PHENHLYL CARBONATE ESTER WITH AMINO ACIDS. N-PROTECTED AMINO ACIDS ARE EMPLOYED IN METHOD OF PEPTIDE SYNTHESIS COMPRISING COUPLING AN N-PROTECTED AMINO ACID OR AN ACTIVE ESTER THEREOF WITH AMINO ACIDS OR PEPTIDES TO PROVIDE N-TERMINAL PROTECTED PEPTIDES. HYDROENOLYSIS OF N-PROTECTED PEPTIDE PRODUCTS OVER 5 PERCENT PD/C AT NEUTRAL OR ACIDIC PH AFFORDS DESIRED PEPTIDES. ACRTYLENIC N-PROTECTING GROUPS PROVIDED ARE READILY CLEAVED IN THE PRESENCE OF AMINO ACIDS OR PEPTIDES HAVING SULFUR CONTAINING GROUP.
Inventors
- 👤 G Southard
Bibliographic Details
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-10-29 | 1977-04-30 | 1977-10-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-10-29 | 1981-04-30 | 1981-10-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-10-29 | 1985-04-30 | 1985-10-30 | $7700.00 | Window Closed / Lapsed |