Thiazines

Abstract

Abstract ANTI-INFLAMMATORY AGENTS OF THE FORMULA (B-ALK-N<(-CO-CH(-Z-R)-(Y)N-C(=)-A=A-A=A-C(=)-))-(X)M WHERE BOTH C''S ARE JOINED ALK MAY BE A STRAIGHT OR BRANCHED CARBON CHAIN OF UP TO 6 CARBON ATOMS; AND B MAY BE A BASIC NITROGEN-CONTAINING RADICAL; AND PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF; N OXIDES AND PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF, AND QUATERNARY AMMONIUM SALTS THEREOF. >C(-R'')-OOC-R WHEREIN R'' IS HYDROGEN, VINYL, ALLYL OR R, OR -CO-, -C(-OH)(-R'')- WHEREIN X MAY BE HYDROGEN, HALOGEN, ALKYL, HALOALKYL, HALOALKOXY, HALOALKYLTHIO, ALKOXY, HYDROXY, ALKYLTHIO, NITRO, ALKYLSULFONYL, AMINO, ALKANOYLAMINO OR MONO- OR DIALKYLAMINO WHEREIN ANY OF THE FOREGOING ALKYL OR SUBSTITUTED ALKYL RADICALS CONTAIN UP TO 8 CARBON ATOMS; M MAY BE 0, 1, 2, 3 OR 4; EACH A MAY BE CARBON, BUT ONE A MAY BE NITROGEN IN ANY POSITION PROVIDED N IS 1; Y MAY BE SULFUR, SULFOXIDE, SULFONYL, OR OXYGEN; N MAY BE 0 TO 1; R MAY BE A STRAIGHT OR BRANCHED ALKYL OF UP TO 8-CARBON ATOMS CYCLOALKL OF FROM 3 TO 8 CARBON ATOMS, PHENYL XSUBSTITUTED PHENYL, PYRIDYL, THIENYL, FURYL, NAPHTHYL, ALKYLPHENYL OR ALKENYLPHENYL WHEREIN THE ALKYL OR ALKENYL RADICAL MAY CONTAIN UP TO 4 CARBON ATOMS EITHER STRAIGHT CHAIN OR BRANCHED; Z MAY BE

Inventors

• 👤 J Krapcho

Bibliographic Details