Substituted n-benzylimidazoles as antimycotic agents

Abstract

Abstract Substituted N-benzylimidazoles of the formula: WHEREIN WHEREIN A, B, X and m are as above defined and Z is chlorine or bromine, with at least the theoretically necessary amount of imidazole, optionally in the presence of an acid acceptor, in a polar organic solvent, at a temperature of from 20* to 150* C. These substituted N-benzylimidazoles are useful as antimycotics and are effective against both yeasts and dermatophytes. These compounds are effective against a wide range of fungi pathogenic to humans and animals. WHEREIN D is CH or N, E is oxygen, sulphur, N-lower alkyl or N-aryl, Y is hydrogen, 1 or 2 lower alkyls, 1 or 2 halogens, aryl or substituted aryl, and N IS 1 OR 2, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA: WHEREIN R1, R2 and R3 are each hydrogen, straight or branched chain lower alkyl or straight or branched chain lower alkenyl, X is hydrogen, lower alkyl, lower alkoxy, lower alkylmercapto, lower alkenylmercapto, trifluoromethyl, halogen, nitro, cyano, amino or amino substituted by 1 or 2 aliphatic moieties, M IS 1 OR 2, A is phenyl; substituted phenyl, pyridyl, lower alkyl or cycloalkyl, B is a 5-membered heteroaromatic ring of the formula:

Inventors

• 👤 W Draber
• 👤 E Regel
• 👤 K Buchel
• 👤 M Plempel

Bibliographic Details