9,9-di-substituted -6,7-benzomorphans
Abstract
Abstract 6,7-BENZOMORPHAN DERIVATIVES HAVING ANALGESIC AND MORPHINEANTAGONISTIC PROPERTIES ARE OF THE FORMULA IN WHICH THE SUBSTITUENTS R are either lower alkyl groups or groups which, together with the carbon atom to which they are bonded, form a cycloaliphatic ring, and the substituents R1, R2 and R3 may or may not be made and, if made, R1 represents either a hydrogen atom or an alkyl, haloalkyl, alkenyl, alkinyl, aralkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl or cycloalkylidine-alkyl group, R2 is an alkyl, aryl, heteroaryl or aralkyl group, and R3 is a hydrogen atom or an hydroxy, alkoxy, alkoxy-alkoxy or acyloxy group. Such 6,7-benzomorphans may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. There are also disclosed methods for producing such 6,7-benzomorphan derivatives, and intermediates useful in such production.
Inventors
- 👤 A Akkerman
- 👤 P Janssen
Bibliographic Details
Claims Analysis
Total Claims: 3References Cited (Backward Citations)
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