Cephalosporanic acid derivatives
Abstract
Abstract NOVEL 7-ISOCYANATO-CEPHALOSPORANIC ACID DERIVATIVES OF THE FORMULA 7-(O=C=N-),2-(E-OOC-),3-(R-CH2-)-2-CEPHEM WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, A PROTECTED HYDROXY GROUP AND ACYLOXY OF AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS AND E IS AN EASILY REMOVABLE, PROTECTIVE ESTER GROUP, AND THE LACTONE OF 7-ISOCYANATO-(DESACETYL-)CEPHALOPORANIC ACID OF THE FORMULA 7-(O=C=N-),2,3-(-COO-CH2-)-2-CEPHEM ARE EXTREMELY USEFUL AS STARTING MATERIALS FOR THE PREPARATION BY A NEW PROCESS OF A GREAT VARIETY OF CEPHALOSPORANIC ACID DERIVATIVES AS THE ISOCYANATO GROUP IN THE 7-POSITION CAN READILY BE CONVERTED INTO A SUBSTITUTED AMINO GROUP AND THEIR PREPARATION AND TO NOVEL CEPHALOSPORANIC ACID DERIVATIVES HAVING ANTIBIOTIC ACTIVITY.
Inventors
- 👤 P Henniger
Bibliographic Details
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