1-amidino-3-(substituted-phenyl) urea antimalarial composition and method of use
Abstract
Abstract Compositions for use as antimalarials which comprise a 1amidino-3-(substituted-phenyl)urea compound of the formula OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF WHEREIN Y4 is halogen, trifluoromethyl, cyano or nitro, and the Y''s are selected from halogen, trifluoromethyl, cyano, nitro, methyl and hydrogen, provided that at least one of the Y''s is a substituent other than hydrogen except where Y4 is cyano or trifluoromethyl, and provided that Y4 and any one of the Y''s are not the same substituent when any one of them is selected from cyano, nitro, trifluoromethyl and methyl, and further provided that not more than two of the Y''s is a substituent other than hydrogen, and a pharmaceuticaly acceptable carrier. And a method for treatment or prophylaxis of malaria in mammals which comprises administering an effective anti-malarial amount of a 1-amidino-3-(substituted-phenyl)urea compound as herein defined or a pharmaceutically acceptable acid addition salt thereof.
Inventors
- 👤 L Walls
Bibliographic Details
Claims Analysis
Total Claims: 13References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1976-09-24 | 1977-03-26 | 1977-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-09-24 | 1981-03-26 | 1981-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-09-24 | 1985-03-26 | 1985-09-25 | $7700.00 | Window Closed / Lapsed |