Process and intermediates for the preparation of n-substituted 6,7-methylenedioxy-4-quinolone derivatives
Abstract
Abstract Novel process for producing antimicrobial 1-substituted-6,7methylenedioxy-4-quinolone-3-carboxylic acid derivatives of the formula, WHEREIN R is alkyl or alkenyl, and R1 is hydrogen or alkyl. The novel process is shown by the following reaction schema: WHEREIN R and R1 are as defined above; R1'' is alkyl; X is halogen; and Y is, for example, halogen. The 1-substituted-6,7methylenedioxy-4-quinolone-3-carboxylic acid derivative of the formula (I) can be also produced directly from the compound of the formula (II) by the reaction with the acid anhydrous or acidic substance. The quinolinium salt of the formula (III) can be, alternatively produced by the process as shown below: WHEREIN R, R1'', X and Y is as defined above.
Inventors
- 👤 T Nakagome
- 👤 H Agui
- 👤 T Mitani
- 👤 M Nakashita
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