2-hydroxy-2(6{40 -methoxynaphth-2{40 - yl) propionitrile and 5{40 -halo derivatives thereof
Abstract
Abstract New compounds, 2-(6''-methoxynaphth-2''-yl)-propylene oxide, 2(6''-methoxynaphth-2''-yl)pro-pionaldoxime, 2-hydroxy-2-(6''methoxynaphth-2''-yl)-propionitrile, 2-(6''-methoxynaphth-2''yl)acrylo-nitrile, 2-(6''-methoxynaphth-2''-yl)acrylic acid, the corresponding 5''-halo compounds and 2-(5''-halo-6''-methoxynaphth2''-yl) propionaldehyde are useful intermediates in producing 2(6''-methoxy-naphth-2''-yl) propionic acid and the corresponding 5''-halo acids from 6-methoxy-2-acetylnaphthalene and the corresponding 5-halo compounds. The 2-propionic acids are antiinflammatory, analgesic, anti-pyretic and anti-pruritic agents. The 2-propionaldehydes, obtained from the 2-acetyl compounds by way of the 2-propylene oxide, can be converted directly to the 2propionic acids by way of the 2-propionaldoximes and the 2propio-nitriles or more directly by Jones oxidation. Alternatively the 2-acrylonitriles, obtained from the 2-acetyl compounds by way of the 2-hydroxy-2-propionitrile, can be converted to the 2-propionic acid by way of the 2-acrylic acid or 2-propionitrile.
Inventors
- 👤 F Alvarez
Bibliographic Details
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