Patent JPS63253792A successfully refreshed from Google Patents.
US3755328A
Expired / Lapsed
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Process for preparing ergot alkaloids
Assignee: Sandoz AG
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Filing: 1972-07-19
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Granted: 1973-08-28
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Expires: 1992-07-19
Abstract
Abstract R1 is hydrogen, lower alkyl, allyl or benzyl and -NH-A is a cyclic polypeptide of the type known in ergot peptide alkaloids. lysergic acid halides, obtained by reaction with thionyl chloride, phosgene or oxalyl chloride are reacted with a salt of the polypeptide amine in the presence of an acid binding agent. Many of the above compounds are of known therapeutic value, and can be described as vaso-active and also have activity on the central nervous system. The invention concerns a novel process for the production of a compound of the formula: IN WHICH X Y IS THE GROUP
Inventors
- 👤 P Stadler
- 👤 A Hofmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 08:08
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
34 words
A process according to Claim 1, wherein the lysergic acid compound is a mixure consisting of 1-R1-lysergic acids, 1-R1-isolysergic acids and 1-R1-6-methyl- Delta 8,9 -ergolene-8-carboxylic acids, where R1 is as defined in claim 1.
Claim 2
Dependent Claim
15 words
A process according to claim 1 in which the N-di-(lower)alkyl-substituted acid amide is dimethyl formamide.
Claim 3
Dependent Claim
25 words
A process according to claim 1, wherein the inert organic solvent is acetonitrile, chloroform, methylene chloride or an excess of dimethyl formamide or mixtures thereof.
Claim 4
Dependent Claim
12 words
A process according to claim 1, wherein the acid-binding agent is pyridine.
Claim 5
Dependent Claim
20 words
A process according to claim 1, wherein the reaction is carried out at a temperature of between -10* and +20*C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-08-27 | 1977-02-26 | 1977-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-08-27 | 1981-02-26 | 1981-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-08-27 | 1985-02-26 | 1985-08-28 | $7700.00 | Window Closed / Lapsed |