US3753969A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for synthesizing pyroglutamylhistidyl-prolinamide
Assignee: Individual
•
Filing: 1969-12-22
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Granted: 1973-08-21
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Expires: 1989-12-22
Abstract
Abstract A METHOD FOR SYNTHESIZING A TRIPEPTIDE, PYROGLUTAMYLHISTIDYL-PROLINAMIDE, WHICH HAS THE SAME POTENT ACTIVITY OF THE THYROTROPIN RELEASING HORMONE OF THE HYPOTHALAMUS GLAND OF MAMMALS IS PROVIDED BY UTILIZING, AS THE STARTING MATERIALS, THE AMINO ACIDS PYROGLUTAMIC ACID, HISTIDINE AND PROLINE. SYNTHESIS OF THE DESIRED RODUCT ISACCOMPLISHED BY COUPLING HISTIDINE WITH EITHER PYROGUTAMIC ACID OR PROLINE AND THEN COUPLING THE RESULTAT PRODUCT WITH THE REMAINING, UNCOUPLED AMINO ACID TO OBTAIN PYROGLUTAMYL-HISTIDYL-PROLINAMIDE.
Inventors
- 👤 K Folkers
- 👤 J Boler
- 👤 J Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 08:33
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K5/0825
Claims Analysis
Total Claims: 0
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References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-08-20 | 1977-02-19 | 1977-08-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-08-20 | 1981-02-19 | 1981-08-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-08-20 | 1985-02-19 | 1985-08-21 | $7700.00 | Window Closed / Lapsed |