Tetrahydropyranyl-dihydro-pge1
Abstract
Abstract 4,5-DISUBSTITUTED - 3 - HYDROXYCYCLOPENTANONES (I) ARE PREPARED BY HYDROGENOLYZING THE CORRESPONDING 4,5-DISUBSTITUTED-2,3-EPOXYCYCLOPENTANONE (IV) WHICH IN TURN IS PROVIDED BY REACTING THE CORRESPONDING 4,5 - DISUBSTITUTED-2-CYCLOPENTEN-1-ONE (III) WITH ALKALINE HYDROGEN PEROXIDE. COMPOUNDS (III) ARE PREPARED BY CYCLIZING THE CORRESPONDING 2,3-DISUBSTITUTED LEVULINALDEHYDE (II) WITH A BASE. THE PRODUCTS OF THE PROCESS ARE BIOLOGICALLY ACTIVE, ESPEICALLY COMPOUND (I) SUBSTITUTED IN THE 4-POSITION WITH 3'':HYDROXYOCTYL AND IN THE 5-POSITION WITH 6''CARBOXYHEXYL. THIS COMPOUND HAS PROSTAGLANDIN-LIKE ACTIVITY, ESPECIALLY BLOOD PRESSURE LOWERING AND BROCHODILATOR ACTIVITY, AND IS A TOTALLY-SYNTHETIC DIHYDROPROSTAGLANDIN E1(DIHYDRO PGE1). THE PROCESSES OF THE INVENTION MAY ALSO BE USED TO OBTAIN COMPOUNDS WITH PROSTAGLANDIN-LIKE ACTIVITY FROM APPROPRIATELY SUBSTITUTED NATURALLY OCCURRING CYCLOPENTANONES, E.G. THOSE ISOLATED FROM THE CARIBBEAN GORGONIAN, PLEXAURA HOMOMALLA.
Inventors
- 👤 D Strike
- 👤 H Smith
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-07-30 | 1977-01-29 | 1977-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-07-30 | 1981-01-29 | 1981-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-07-30 | 1985-01-29 | 1985-07-31 | $7700.00 | Window Closed / Lapsed |