Bis-thioureido-benzenes and preparation thereof

Abstract

Abstract THE COMPOUNDS HAVING EITHER FORMULA R-Y-CO-NH-C(=S)-N(-R2)-(XN-1,2-PHENYLENE)-N(-R3)-C(=S)- NH-CO-Y-R1, OR R-Y-C(-O(-))-N-C(-S(-))-N(-R2)-(XN-1,2- PHENYLENE)-N(-R3)-C(-S(-))-N-C(-O(-))-Y-R1 M(+4) WHERE BOTH O''S AND S''S ARE ATTACHED TO M (WHEREIN EACH OF R AND R1 REPRESENTS ALKYL OF 1 TO 12 CARBON ATOMS, ALKYL OF 1 TO 2 CARBON ATOMS SUBSTITUTED WITH HALOGEN, METHOXY OR PHENYL, ALKENYL HAVING 2 TO 3 CARBON ATOMS, ALKNYL HAVING 2 TO 3 CARBON ATOMS, ARYL OR ARYL SUBSTITUTED WITH HALOGEN, NITRO OR METHYL; EACH OF R2 AND R3 REPRESENTS HYDROGEN OR METHYL; X REPRESENTS HALOGEN, NITRO OR METHYL; N REPRESENTS INTEGER OF 0-3; Y REPRESENTS OXYGEN OR SULFUR AND M REPRESENTS METAL) ARE PREPARED IN ACCORDANCE WITH THE FOLLOWING EQUATIONS: 1-(R2-NH-),2-(R3-NH-),XN-BENZENE AND 2(SCN-CO-Y-R) -> R-Y-CO-NH-C(=S)-N(-R2)-(XN-1,2-PHENYLENE)-N(-R3)-C(=S)- NH-CO-Y-R1 AND 2(M''-OH) -> R-Y-CO-N(-M'')-C(=S)- N(-R2)-(XN-1,2-PHENYLENE)-N(-R3)-C(=S)-N(-M'')-CO-Y-R1 AND M(+2) -> R-Y-C(-O(-))-N-C(-S(-))-N(-R2)-(XN-1,2-PHENYL- ENE)-N(-R3)-C(-S(-))-N-C(-O(-))-Y-R1 M(+4) WHERE BOTH O''S AND S''S ARE ATTACHED TO M WHEREIN M'' REPRESENTS ALKALI METAL ATOM AND THE NOVEL COMPOUNDS HAVE BROAD FUNGICIDAL ACTIVITY WITH VERY LOW MAMMALIAN TOXICITY.

Inventors

• 👤 Kinpei Kato
• 👤 Teruhisa Noguchi
• 👤 Koshin Miyazaki
• 👤 Keisuke Kohmoto
• 👤 Sho Hashimoto
• 👤 Daigaku Takiguchi
• 👤 Yasushi Yasuda

Bibliographic Details