Therapeutic compositions and method

Abstract

Abstract A COMPOSITION HAVING BRADYCARDIA AND ISOPROTERENOL ACTIVITY COMPRISING AT LEAST ONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF RACEMATES OF 1-PHENOXY-2-HYDROXY-3-TERT.-BUTYLAMINO PROPANES OF THE FORMULA (R1,R2,R-PHENYL)-O-CH2-CH(-OH)-CH2-NH-C(-CH3)3 WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF ALKYNYLOXY OF 2 TO 4 CARBON ATOMS, -(CH2)X+1-OH, -(CH2)X-CN AND -(CH2)X-NH2, WHERE X IS AN INTEGER FROM 0 TO 3, COOH AND COOR'' WHERE R'' IS ALKYL OF 1 TO 4 CARBON ATOMS, R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKOXY AND ALKYLTHIO OF 1 TO 4 CARBON ATOMS, -CN AND ALKENYL AND ALKYNYL OF 2 TO 4 CARBON ATOMS AND R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN AND ALKYL AND ALKOXY OF 1 TO 4 CARBON ATOMS, THEIR OPTICALLY ACTIVE ISOMERS AND THEIR NONTOXIC, PHARRMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF SAID RACEMATES AND SAID OPTICALLY ACTIVE ISOMERS AND A MAJOR AMOUNT OF A PHARMACEUTICAL CARRIER AND METHOD OF PRODUCING BRADYCARDIA AND SUPPRESSING TACHYCARDIA EFFECTS OF N-ISOPROPYL-NORADRENALINE IN WARM-BLOODED ANIMALS.

Inventors

• 👤 K Zeile
• 👤 H Koppe
• 👤 A Engelhardt

Bibliographic Details