US3735761A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypodermic devices
Assignee: Ampoules Inc
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Filing: 1971-02-11
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Granted: 1973-05-29
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Expires: 1991-02-11
Abstract
Abstract Hypodermic ampoules of the contained-needle type, a method of assembling and filing such ampoules, and combinations of such ampoules with so-called ''''applicators'''' for actuating the ampoules to make injections are disclosed. Each of several ampoule forms has a plurality of cylindrical, medicamentcontaining chambers and a plunger closing one end of one of the chambers. A hollow needle is fixed to the plunger and is initially contained within such a chamber. The other end of the ampoule is sealed by a diaphragm which is pressed against a beaded end portion of a cylinder and is sealed thereto by a cupshaped clip which snaps over the beaded end portion to thereby compress the diaphragm against the end portion. The clip has a peripheral rim about a recessed bottom end which stretches the patient''s skin to facilitate the injection. According to the invention, the ampoule includes multiple chambers for premixing a medicament with at least one other medicament and dispensing the mixture by, for example, injecting it either subcutaneously or intramuscularly.
Inventors
- 👤 A Hurschman
- 👤 T Schiller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:15
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/178; A61M5/31; A61M5/32; A61M5/28; A61M5/284; A61M5/285; A61M5/288; A61M5/329
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
289 words
A multichamber ampoule for mixing and discharging medicaments, comprising a first cylinder, a first diaphragm sealed to and closing one end of said first cylinder, a plunger slidably disposed in the other end of said first cylinder to provide a first chamber between said plunger and first diaphragm, a hollow needle disposed in said first chamber for movement with said plunger toward said first diaphragm and having an open end adjacent said plunger and an opposite pointed discharge end adjacent said first diaphragm, and a powder medicament in said first chamber; a second cylInder axially aligned with said first cylinder and having one end closed by insertion of said first diaphragm therein with a peripheral portion of the first diaphragm in axial sliding engagement with the inner surface thereof, a second diaphragm closing the other end of said second cylinder, said first and second diaphragms and second cylinder, together, defining a second chamber, and a fluid medicament in said second chamber; whereby said fluid and solid medicaments may be mixed preparatory to discharge thereof by first moving said plunger and needle sufficiently toward said first diaphragm to project the pointed end of the needle through said first diaphragm to establish communication between the two chambers and by then moving said first cylinder, first diaphragm, plunger, and needle as a unit toward said second diaphragm to progressively reduce the volume of said second chamber substantially to zero and thereby express said liquid medicament through the needle into the first chamber while bringing said first and second diaphragms substantially into engagement and disposing the pointed end of said needle in position to project the needle through said second diaphragm upon further movement of said plunger toward said first and second diaphragms.
Claim 2
Dependent Claim
289 words
A multichamber ampoule for mixing and discharging medicaments, comprising a first cylinder, a first diaphragm sealed to and closing one end of said first cylinder, a plunger slidably disposed in the other end of said first cylinder to provide a first chamber between said plunger and first diaphragm, a hollow needle disposed in said first chamber for movement with said plunger toward said first diaphragm and having an open end adjacent said plunger and an opposite pointed discharge end adjacent said first diaphragm, and a powder medicament in said first chamber; a second cylInder axially aligned with said first cylinder and having one end closed by insertion of said first diaphragm therein with a peripheral portion of the first diaphragm in axial sliding engagement with the inner surface thereof, a second diaphragm closing the other end of said second cylinder, said first and second diaphragms and second cylinder, together, defining a second chamber, and a fluid medicament in said second chamber; whereby said fluid and solid medicaments may be mixed preparatory to discharge thereof by first moving said plunger and needle sufficiently toward said first diaphragm to project the pointed end of the needle through said first diaphragm to establish communication between the two chambers and by then moving said first cylinder, first diaphragm, plunger, and needle as a unit toward said second diaphragm to progressively reduce the volume of said second chamber substantially to zero and thereby express said liquid medicament through the needle into the first chamber while bringing said first and second diaphragms substantially into engagement and disposing the pointed end of said needle in position to project the needle through said second diaphragm upon further movement of said plunger toward said first and second diaphragms.
Claim 3
Dependent Claim
25 words
A multichamber ampoule according to claim 1, wherein the outer diameter of said first cylinder is less than the inner diameter of said second cylinder.
Claim 4
Dependent Claim
24 words
A multichamber ampoule according to claim 1, wherein the volume of said first chamber is substantially equal to the volume of said second chamber.
Claim 5
Dependent Claim
148 words
A multichamber ampoule according to claim 1, wherein the volume of said first chamber sufficiently exceeds the volume of said second chamber so that the volume of the two medicaments in said first chamber after mixing the medicaments therein is substantially less than the remaining volume of said first chamber, whereby, prior to expelling the mixed contents of the first chamber, said plunger may be further advanced toward said first and second diaphragms to extend a portion of the length of said needle through and beyond said second diaphragm in an exposed condition for projection into a patient to the depth of muscle tissue to be injected, and said plunger may then be moved further toward said first and second diaphragms to progressively expel the mixed contents of said first chamber through said needle and into said muscle tissue while further advancing said needle into said muscle tissue.
Claim 6
Dependent Claim
101 words
A multichamber ampoule according to claim 1, in which at least one additional diaphragm is disposed in said second chamber between said first and second diaphragms so as to divide said second chamber into a plurality of smaller chambers, and a corresponding plurality of different liquid medicaments respectively substantially fill said smaller chambers, whereby each of said liquid medicaments, one after another, may be caused to flow through said needle into said first chamber by progressive movement of said first diaphragm, first cylinder, plunger, and needle, as a unit, to bring all of said diaphragms substantially into engagement with one another.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-05-28 | 1976-11-27 | 1977-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-05-28 | 1980-11-27 | 1981-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-05-28 | 1984-11-27 | 1985-05-29 | $7700.00 | Window Closed / Lapsed |