Determining and reversing anticomplementary activity in complement fixation test for australia antigen
Abstract
Abstract ANTIGEN OR ANTIBODY IS ADDED TO AN APPROPRIATE BIOLOGIC MATERIAL TO REACT WITH HEPATITIS ASSOCIATED ANTIBODY OR ANTIGEN, RESPECTIVELY, IF PRESENT. THE REACTION MIXTURE IS INCUBATED WITH COMPLEMENT TO FIX THE LATTER. TITRATION OF NON-FIXED COMPLEMENT WITH STANDARDIZED CELLS REVEALS PRESENCE OR ABSENCE AND AMOUNT OF HEPATITIS ASSOCIATED ANTIBODIES OR ANTIGENS IN THE SUBSTANCE TESTED, THEREBY REVEALING THE PRESENCE OF DISEASE OR IMMUNITY TO THE DISEASE IF SUBSTANCES FROM AN INDIVIDUAL ARE TESTED, OR THE PRESENCE OF VIRUS THAN CAN TRANSMIT DISEASE OR ANTIBODY THAT MAY NEUTRALIZE VIRUS IN BIOLOGICAL MATERIALS THAT ARE TESTED. IN SUCH TEST PROCEDURE, ANTICOMPLEMENTARY ACTIVITY MAY BE DETECTED. IT CAN BE REVERSED BY ADDING TO THE ANTICOMPLEMENTARY BIOLOGIC MATERIAL A LARGE EXCESS OF THE ANTIGEN OR THE ANTIBODY.
Inventors
- 👤 N Shulman
Bibliographic Details
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