Abstract The present invention relates to a water-soluble composition of N(4,6-dimethyl-2-pyrimidinyl)sulfanilamide (hereinafter called ''''sulfadimidine'''') and 2,4-diamino-5-chlorophenyl-6-ethylpyrimidine (hereinafter called ''''pyrimethamine'''') solubilized with glycols. for oral administration to animals in the form of an aqueous solution thereof, said composition comprising free sulfadimidine and free pyrimethamine both dissolved in a water miscible organic solvent selected from the group consisting of propylene glycol, tetrahydrofurfurylethyleneglycol ether, polyethylene glycol, and methylidene glycerol, and mixtures thereof, the ratio of pyrimethamine: sulfadimidine being between 1:20 to 1:4 by weight.
A palatable aqueous solution for oral administration to animals comprising the composition of claim 1 dissolved in water.
Claim 2
Dependent Claim
26 words
An aqueous solution according to claim 2, wherein said solution comprises 0.01-0.2 part by weight sulfadimidine and 0.001-0.05 part by weight pyrimethamine per 100 parts water.
Claim 3
Dependent Claim
20 words
An aqueous solution according to claim 4, which comprises 0.02-0.06 parts sulfadimidine and 0.002-0.01 part pyrimethamine per 100 parts water.
Claim 4
Dependent Claim
24 words
A method for the treatment of diseased animals amenable to sulfadimidine-pyrimethamine therapy which comprises orally administering to such animals the composition of claim 2.
Claim 5
Dependent Claim
32 words
A method according to claim 5, wherein the composition of claim 1 is dissolved in the drinking water of the animals which are then caused to drink the thus formed drinking water.