Indol-2-ylphenylacetic acids and esters
Abstract
Abstract THE PRESENT INVENTION DISCLOSES INDOL-2-YLPHENYLACETIC ACIDS AND ESTERS WHEREIN THE INDOL-2-YL RADICAL IS ATTACHED TO THE PHENYL RADICAL OF THE PHENYLACETIC ACID MOIETY AT THE META AND PARA POSITIONS. THE INDOL-2-YLPHENYLACETIC ACIDS ARE USEFUL IN AMELIORATING DISTRESS IN ANIMALS CAUSED BY INFLAMED TISSUED. THE ESTERS OF THE INDOL-2-YLPHENYLACETIC ACIDS ARE USEFUL PRECURSORS. THE NOVEL COMPOUNDS ARE PREPARED BY REACTING PHENYLHYDRAZINE AND MONOSUBSTITUTED PHENYLHYDRAZINES WITH LOWER ALKYL M- AND P-ACETYLPHENYLACETATES TO GIVE THE CORRESPONDING HYDRAZONES. THE LATTER ARE CYCLIZED IN POLYPHOSPHORIC ACID OR IN AN ACIDIC ALCOHOLIC MEDIUM TO THE INDOL-2-YLPHENYLACETATES WHICH ARE HYDROLYZED TO THE ACIDS. THE PRECURSR HYDRAZONES HAVING THE FREE CARBOXYLIC ACID MOIETY ARE ALSO USEFUL IN AMELIORATING INFLAMED TISSUE.
Inventors
- 👤 R Duncan
- 👤 R Boswell
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-04-09 | 1976-10-09 | 1977-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-04-09 | 1980-10-09 | 1981-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-04-09 | 1984-10-09 | 1985-04-10 | $7700.00 | Window Closed / Lapsed |