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US3720690A Expired / Lapsed US ⏱️ 0.0 years remaining

Pharmaceutically active bis-carboxychromone compounds

Assignee: Fisons Pharmaceuticals Ltd
•
Filing: 1970-05-08
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Granted: 1973-03-13
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Expires: 1990-05-08
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Abstract

Abstract Novel compounds of the formula THE SUBSTITUENTS P, Q, R, P1, Q1 and R1 being defined in the specification, useful for inhibiting the effects of antibodyantigen reaction, are provided, as well as a method for the preparation thereof and pharmaceutical compositions containing these compounds.

Inventors

  • 👤 J King
  • 👤 G Lord

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-28 20:53
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24

Claims Analysis

Total Claims: 16
Claim 1
Independent Claim 160 words
A compound selected from the group consisting of the formula and pharmaceutically acceptable salts, esters derived from alcohols containing 1-10 carbon atoms and amides derived from ammonia, primary or secondary lower alkyl amines or aniline, wherein X iS selected from the group consisting of benzene, naphthalene, cyclopentadiene, cycloheptane, cyclopentane, cyclohexane, pyridine, piperidine, piperazine, pyrazine, pyrrolidine, morpholine and pyrone rings, optionally substituted by hydroxy, halogen or lower alkyl, and straight or branched, saturated or unsaturated hydrocarbon chains containing 2-10 carbon atoms, optionally interrupted by at least one of the carbocyclic or heterocyclic rings specified above or by an oxygen or nitrogen atom, and P, Q, R, P1, Q1 and R1 are the same or different and each is selected from the group consisting of hydrogen, nitro, amino, amino lower alkoxy, cyano, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkenyloxy and lower alkynyloxy groups, optionally substituted by at least one of hydroxy, halogen, lower alkyl and lower alkoxy.
Claim 2
Dependent Claim 160 words
A compound selected from the group consisting of the formula and pharmaceutically acceptable salts, esters derived from alcohols containing 1-10 carbon atoms and amides derived from ammonia, primary or secondary lower alkyl amines or aniline, wherein X iS selected from the group consisting of benzene, naphthalene, cyclopentadiene, cycloheptane, cyclopentane, cyclohexane, pyridine, piperidine, piperazine, pyrazine, pyrrolidine, morpholine and pyrone rings, optionally substituted by hydroxy, halogen or lower alkyl, and straight or branched, saturated or unsaturated hydrocarbon chains containing 2-10 carbon atoms, optionally interrupted by at least one of the carbocyclic or heterocyclic rings specified above or by an oxygen or nitrogen atom, and P, Q, R, P1, Q1 and R1 are the same or different and each is selected from the group consisting of hydrogen, nitro, amino, amino lower alkoxy, cyano, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkenyloxy and lower alkynyloxy groups, optionally substituted by at least one of hydroxy, halogen, lower alkyl and lower alkoxy.
Claim 3
Dependent Claim 68 words
The compound according to claim 1, wherein X is selected from the group consisting of pyridine, piperidine, piperazine, pyrazine, pyrrolidine and morpholine rings and saturated or unsaturated, straight or branched polymethylene chains containing 2-10 carbon atoms, optionally substituted by at least one of halogen, carbonyl oxygen, lower alkyl, lower alkoxy and hydroxyl, and which chains may optionally be interrupted by at least one of oxygen atoms and groups.
Claim 4
Dependent Claim 29 words
The compound according to claim 1, wherein X is selected from the group consisting of -CONH(CH2)pNHCO-, -CH2CHOHCH2- and -(CH2)p wherein p is an integer of from 2 to 8.
Claim 5
Dependent Claim 18 words
The compound according to claim 1 in the form of a the pharmaceutically acceptable salt, ester or amide.
Claim 6
Dependent Claim 13 words
The compound according to claim 1 in the form of a sodium salt.
Claim 7
Dependent Claim 8 words
The compound according to claim 1, namely 1,5-Bis(2-carboxychromon-6-yl)pentane.
Claim 8
Dependent Claim 8 words
The compound according to claim 1, namely 1,6-Bis(2-carboxychromon-6-yl)hexane.
Claim 9
Dependent Claim 8 words
The compound according to claim 1, namely 1,3-Bis(2-carboxychromon-6-yl)propane.
Claim 10
Dependent Claim 8 words
The compound according to claim 1, namely 1,5-Bis(2-carboxychromon-6-yl)pentan-3-ol.
Claim 11
Dependent Claim 8 words
The compound according to claim 1, namely 1,5-Bis(2-carboxychromon-6-yl)pentan-2-ene.
Claim 12
Dependent Claim 8 words
The compound according to claim 1, namely 1,5-Bis(2-carboxychromon-8-yl)pentane.
Claim 13
Dependent Claim 8 words
The compound according to claim 1, namely N,N''-Bis(2-carboxychromon-6-yl)piperazine.
Claim 14
Dependent Claim 9 words
The compound according to claim 1, namely N,N''-Bis(2-carboxychromon-6-yl carbonyl)-1,2-diamino-ethane.
Claim 15
Dependent Claim 9 words
The compound according to claim 1, namely N,N''-Bis(2-carboxychromon-6-yl carbonyl)-1,3-diamino-propane.
Claim 16
Dependent Claim 9 words
The compound according to claim 1, namely N,N''-Bis(2-carboxychromon-6-yl carbonyl)-1,6-diamino-hexane.

References Cited (Backward Citations)

US3427324A Cited
US3484445A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1976-03-12 1976-09-11 1977-03-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1980-03-12 1980-09-11 1981-03-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1984-03-12 1984-09-11 1985-03-13 $7700.00 Window Closed / Lapsed

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