US3719673A
Expired / Lapsed
US
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Derivatives of 7-aminocephalosporanic acid
Assignee: Novartis Corp
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Filing: 1970-11-17
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Granted: 1973-03-06
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Expires: 1990-11-17
Abstract
Abstract IN WHICH R1 and R2 each represent a hydrogen atom or an unsubstituted or substituted monovalent hydrocarbon radical or an unsubstituted or substituted monovalent heterocyclyl radical bound by way of a carbon atom, or together represent a divalent hydrocarbon radical that may be interrupted by one or more hetero atoms and/or substituted, and R3 represents a heterocyclyl radical having aromatic character which is bound to the sulphur atom by way of a carbon atom and which contains at least two nitrogen atoms and a further hetero atom selected from the group consisting of nitrogen, oxygen and sulphur. They have antimicrotial activity. Compounds of the formula
Inventors
- 👤 H Bickel
- 👤 R Bosshardt
- 👤 J Mueller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:54
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/36
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
5 words
A compound of formula I
Claim 2
Dependent Claim
5 words
A compound of formula I
Claim 3
Dependent Claim
36 words
A compound of formula I as claimed in claim 1, in which R1 and R2 each represent a hydrogen atom and R3 has the meaning as indicated in claim 1, or a therapeutically acceptable salt thereof.
Claim 4
Dependent Claim
46 words
A compound of formula I as claimed in claim 1, in which R1 represents a hydrogen atom and R2 has the meaning as indicated in claim 15, other than hydrogen, and R3 has the meaning as indicated in claim 15, or a therapeutically acceptable salt thereof.
Claim 5
Dependent Claim
62 words
A compound of formula I as claimed in claim 1, in which R1 represents a hydrogen atom and R2 is phenyl or phenyl substituted by one or more members selected from the group consisting of halogen atoms, lower alkyl, lower alkoxy groups and the nitro group, and R3 has the meaning as indicated in claim 15, or a therapeutically acceptable salt thereof.
Claim 6
Dependent Claim
63 words
A compound of formula I as claimed in claim 1, in which R1 and R2 together represent a radical of the formula in which R''1 and R''2 each denote a lower alkyl radical or together represent an alkylene radical having up to six carbon atoms, and in which R3 has the meaning as indicated in claim 1, or a therapeutically acceptable salt thereof.
Claim 7
Dependent Claim
42 words
A compound of formula I as claimed in claim 1, in which R1 and R2 have the meaning as indicated in claim 1 in which R3 is an unsubstituted heterocyclyl radical selected from the group consisting of triazolyl, tetrazolyl, thiadiazolyl and oxadiazolyl.
Claim 8
Dependent Claim
39 words
A compound of formula I as claimed in claim 1, in which R1 and R2 have the meaning as indicated in claim 1 and in which R3 is an unsubstituted 1,3,4-thiadiazolyl(5)- or 1,2,4-thiadiazolyl(5)-radical, or a therapeutically acceptable salt thereof.
Claim 9
Dependent Claim
38 words
A compound of formula I as claimed in claim 1, in which R1 and R2 have the meaning as indicated in claim 1 and in which R3 is an unsubstituted tetrazolyl(5)- radical, or a therapeutically acceptable salt thereof.
Claim 10
Dependent Claim
44 words
A compound of formula I as claimed in claim 1, in which R1 and R2 represent hydrogen and in which R3 is a member selected from the group consisting of 1,3,4-thiadiazol-5-yl, 2-methyl-1,3, 4-thiadiazol-5-yl, 3-methyl-1,2,4-triazol-5-yl, 2-methylthio-1,3, 4-thiadiazol-5-yl and 1-methyl-tetrazol-5-yl, or a therapeutically acceptable salt thereof.
Claim 11
Dependent Claim
18 words
A compound as claimed in claim 1 and being 7-cyanacetylamino-3-desacetoxy-3-(2-methyl-1,3,4-thiadiazol-5-ylthio) -cephalosporanic acid, or a therapeutically acceptable salt thereof.
Claim 12
Dependent Claim
18 words
A compound as claimed in claim 1 and being 7-cyanacetylamino-3-desacetoxy-3-(3-methyl-1,2,4-thiadiazol-5-ylthio) -cephalosporanic acid, or a therapeutically acceptable salt thereof.
Claim 13
Dependent Claim
18 words
A compound as claimed in claim 1 and being 7-cyanacetylamino-3-desacetoxy-3-(1-methyl-tetrazol-5-ylthio) -cephalosporanic acid, or a therapeutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-03-05 | 1976-09-04 | 1977-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-03-05 | 1980-09-04 | 1981-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-03-05 | 1984-09-04 | 1985-03-06 | $7700.00 | Window Closed / Lapsed |