US3718743A
Expired / Lapsed
US
⏱️ 0.0 years remaining
5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation
Assignee: Merck and Co Inc
•
Filing: 1970-11-19
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Granted: 1973-02-27
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Expires: 1990-11-19
Abstract
Abstract Novel 5-phenyl-2-piperidone and 5-phenyl-2-thiopiperidone compounds and the processes for preparing the same are disclosed. In addition the invention concerns piperidones and thiopiperidones which exhibit anti-inflammatory properties and also possess an effective degree of anti-pyretic and analgesic activity.
Inventors
- 👤 T Shen
- 👤 B Witzel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 03:14
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/64; C07C; C07C255/00; C07D211/00; C07D211/02; C07D211/04; C07D211/68; C07D211/72; C07D211/74; C07D211/76
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
30 words
A method according to claim 1 where R is hydrogen, loweralkyl, or acyl; W is hydrogen or loweralkyl; and W and Y are each hydrogen, nitro, halogen, loweralkyl or haloloweralkyl.
Claim 2
Dependent Claim
24 words
A method according to claim 2 wherein the compound is selected from the group consisting of 5-phenyl-2-piperidone, 5-(o-chlorophenyl)-2-piperidone, 5-(p-chlorophenyl)-2-piperidone, 5-(o-fluorophenyl)-2-piperidone, 5-(o-methylphenyl)-2-piperidone, 5-(m-trifluoro-methylphenyl)-2-piperidone and 3-methyl-5-phenyl-2-piperidone.
Claim 3
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 5-phenyl-2-piperidone.
Claim 4
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 5-(o-chlorophenyl)-2-piperidone.
Claim 5
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 5-(p-chlorophenyl)-2-piperidone.
Claim 6
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 5-(o-fluorophenyl)-2-piperidone.
Claim 7
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 5-(o-methylphenyl)-2-piperidone.
Claim 8
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 5-(m-trifluoromethylphenyl)-2-piperidone.
Claim 9
Dependent Claim
11 words
A method according to claim 3 wherein the compound is 3-methyl-5-phenyl-2-piperidone.
Claim 10
Dependent Claim
49 words
A tablet, capsule or suppository preparation in dosage unit for administration to obtain an antiinflammatory, anti-pyretic and analgesic effect, comprising, per dosage unit, an inert pharmaceutical carrier and an effective non-toxic amount within the range from about 5 milligrams to about 5 grams of a compound of the formula:
Claim 11
Dependent Claim
30 words
A preparation according to claim 11 where R is hydrogen, loweralkyl or acyl; W is hydrogen or loweralkyl; and X and Y are each hydrogen, nitro, halogen, loweralkyl or haloloweralkyl.
Claim 12
Dependent Claim
24 words
A preparation according to claim 12 wherein the compound is selected from the group consisting of 5-phenyl-2-piperidone, 5-(o-chlorophenyl)-2-piperidone, 5-(p-chlorophenyl)-2-piperidone, 5-(o-fluorophenyl)-2-piperidone, 5-(o-methylphenyl)-2-piperidone, 5-m-trifluoro-methylphenyl)-2-piperidone, and 3-methyl-5-phenyl-2-piperidone.
Claim 13
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 5-phenyl-2-piperidone.
Claim 14
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 5-(o-chlorophenyl)-2-piperidone.
Claim 15
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 5-(p-chlorophenyl)-2-piperidone.
Claim 16
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 5-(o-fluorophenyl)-2-piperidone.
Claim 17
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 5-(o-methylphenyl)-2-piperidone.
Claim 18
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 5-(m-trifluoromethylphenyl)-2-piperidone.
Claim 19
Dependent Claim
11 words
A preparation according to claim 13 wherein the compound is 3-methyl-5-phenyl-2-piperidone.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-02-27 | 1976-08-28 | 1977-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-02-27 | 1980-08-28 | 1981-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-02-27 | 1984-08-28 | 1985-02-27 | $7700.00 | Window Closed / Lapsed |