US3718668A
Expired / Lapsed
US
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Benzodipyrones
Assignee: Fisons Ltd
•
Filing: 1970-08-07
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Granted: 1973-02-27
•
Expires: 1990-08-07
Abstract
Abstract Certain benzodipyrones, e.g., 4,10-dioxo-2,8-dicarboxy-5methoxy-4H,10H-benzo(1,2-b:3,4-b'') dipyran disodium salt and many others which are disclosed, inhibit the release and/or action of toxic products which arise from the combination of certain types of antibody and specific antigen; and are useful in the treatment of conditions - such as asthma, hay fever, etc. - in which antigen reactions are responsible for said conditions.
Inventors
- 👤 Hugh Cairns
- 👤 Robert Minshull
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:37
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07C59/70; C07C59/76; C07C59/90; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24; C07D493/00; C07D493/02; C07D493/04
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
57 words
A compound according to claim 1, wherein those of P, Q, R and T not forming a-CO-CR1 C(COOH)-O- chain are hydrogen or halogen, hydroxy, nitro, lower alkyl, lower alkenyl, benzyl, phenyl, lower alkoxy, lower alkenyloxy, phenyl, benzyloxy or the fused ring substituents specified in claim 1 or such groups carrying a halogen, hydroxy or lower alkoxy substituent.
Claim 2
Dependent Claim
48 words
A compound according to claim 1, wherein those of P, Q, R and T not forming a -CO-CR1 C(COOH)-O- chain are hydrogen, chlorine, bromine, nitro or lower alkyl or alkoxy grOup containing from one to six carbon atoms which may carry a hydroxy, lower alkoxy or phenyl substituent.
Claim 3
Dependent Claim
76 words
A compound according to chain 1 and of formula, wherein an adjacent pair of P1, Q1, R1 and T1 together forms the chain -CO-CH C(COOH)-O- which may be bonded to the benzene ring in either sense; and the other two P1, Q1, R1 and T1 may be the same or different and each is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, or a lower alkyl or alkoxy group carrying a hydroxy, lower alkoxy or phenyl substituent.
Claim 4
Dependent Claim
99 words
A compound according to claim 1 in which those of P, Q, R and T which do not form a chain -COCR1 C(COOH)-O- are selected from the group consisting of hydrogen, hydroxy, nitro, halogen, lower alkyl, lower alkoxy or lower alkenyloxy groups (which groups may carry a hydroxy or lower alkoxy substituent), a benzyl group or an adjacent pair of P, Q, R and T may, form a chain -O-(CH2)2, and each R1 is selected from the group consisting of hydrogen, alkyl containing from one to 10 carbon atoms, alkoxy containing from 1 to 10 carbon atoms and phenyl.
Claim 5
Dependent Claim
40 words
A compound according to claim 1 in which R1 is hydrogen and those of P,Q,R and T which do not form a -COCR1 (COOH)-O-chain are selected from methoxy, hydroxy, nitro, methyl, bromo, benzyloxy, ethyl, chloro, allyloxy, butyl, propyl and pentyl.
Claim 6
Dependent Claim
16 words
A compound according to claim 1, vis., 4, 10-Dioxo-5-methoxy-2,8-dicarboxy-4H,10H-benzo (1,2-b:-3,4-b'') dipyran and the sodium salt thereof.
Claim 7
Dependent Claim
17 words
A compound according to claim 1, vis., 4,10-Dioxo-2,8-dicarboxy-5-hydroxy-4H 10H-benzo (1,2-b: 3,4-b'') dipyran and the sodium salt thereof.
Claim 8
Dependent Claim
16 words
A compound according to claim 1, vis., 4,10-Dioxo-5-methyl-2, 8-dicarboxy-4H,10H-benzo (1,2-b:3,4-b'') dipyran and the sodium salt thereof.
Claim 9
Dependent Claim
18 words
A compound according to claim 1, vis., 2,8-Diethoxycarbonyl-4, 10-dioxo-4H, 10H-benzo (1,2b: 3,4-b'') dipyran and the sodium salt thereof.
Claim 10
Dependent Claim
15 words
A compound according to claim 1, vis., 2,8-Dicarboxy-4,6-dioxo-10-nitro-4H,6H-benzo (1,2-b:5,4-b'') dipyran and the sodium salt thereof.
Claim 11
Dependent Claim
19 words
A compound according to claim 1, vis., 2,8-Dicarboxy-4,6-dioxo-10 methyl -4H, 6H-benzo (1,2-b: 5,4-b'') dipyran and the sodium salt thereof.
Claim 12
Dependent Claim
15 words
A compound according to claim 1, vis., 6-Bromo-2,8-dicarboxy-4,10-dioxo-5-hydroxy-4H,10H-benzo (1,2-b:3,4-b'') dipyran and the sodium salt thereof.
Claim 13
Dependent Claim
15 words
A compound according to claim 1, vis., 4,6-dioxo-2,8-dicarboxy-4H,6H-benzo (1,2-b:5,4-b'') dipyran and the sodium salt thereof.
Claim 14
Dependent Claim
15 words
A compound according to claim 1, vis., 5-Benzyloxy-4,10-dioxo-2,8-dicarboxy-4H,10H-benzo (1,2-b:3,4-b'') dipyran and the sodium salt thereof.
Claim 15
Dependent Claim
15 words
A compound according to claim 1, vis., 5-Methoxy-4,6-dioxo-2,8-dicarboxy-4H,6H-benzo (1,2b:-5,4b'') dipyran and the sodium salt thereof.
Claim 16
Dependent Claim
17 words
A compound according to claim 1, vis., 4,10-Dioxo-6-ethyl-2, 8-dicarboxy-4H,10H-benzo (1,2-b: 3,4-b'') dipyran and the sodium salt thereof.
Claim 17
Dependent Claim
16 words
A compound according to claim 1, vis., 4,6-Dioxo-2,8-dicarboxy-10-ethyl-4H, 6H-benzo (1,2-b:5,4-b'') dipyran and the sodium salt thereof.
Claim 18
Dependent Claim
16 words
A compound according to claim 1, vis., 6,10-dicarboxy-4-methyl-2,8,12-trioxo-2H,8H,12H-benzo (1,2-b: 3,4-b'': 5,6-b'''')tripyran and the sodium salt thereof.
Claim 19
Dependent Claim
10 words
A compound according to claim 1, vis., 4,10-dioxo-2,8-dicarboxy-5-allyloxy-4H,10H-benzo (1,2-b:3,4-b'') dipyran
Claim 20
Dependent Claim
11 words
A compound according to claim 1, vis., 10-Butyl-2,8-dicarboxy-4,6-dioxo-4H,6H-benzo (1,2-b: 5,4-b'') dipyran
Claim 21
Dependent Claim
17 words
A compound according to claim 1, vis., 2,6,10,10-Tricarboxy-4,8,12-trioxo-4H,8H12H-benzo (1,2-b: 3,4-b'': 5,6-b'''') tripyran and the sodium salt thereof.
Claim 22
Dependent Claim
11 words
A compound according to claim 1, vis., 2,8-Dicarboxy-4,6-dioxo-10-n-pentyl-4H,6H-benzo (1,2-b: 5,4-b'') dipyran
Claim 23
Dependent Claim
11 words
A compound according to claim 1, vis., 2,8-Dicarboxy-5-methoxy-4,6-dioxo-10-propyl-4H,6H-benzo (1,2-b: 5,4-b'') dipyran
Claim 24
Dependent Claim
11 words
A compound according to claim 1, vis., 2,8-Dicarboxy-5-methoxy-4,10-dioxo-6-propyl-4H,10H-benzo (1,2-b: 3,4-b'') dipyran
Claim 25
Dependent Claim
11 words
A compound according to claim 1, vis., 2,8-Dicarboxy-10-ethyl-5-methyl-4,6-dioxo-4H,6H-benzo (1,2-b: 5,4-b'') dipyran
Claim 26
Dependent Claim
16 words
A compound according to claim 1, vis., 2,7-Dicarboxy-4,9-dioxo-4H,9H-benzo (1,2-b: 4,5-b'') dipyran and the sodium salt thereof.
Claim 27
Dependent Claim
10 words
A compound according to claim 1, vis., 4,10-dioxo-6-chloro-2,8-dicarboxy-4H,10H-benzo (1,2-b:3,4-b'') dipyran
References Cited (Backward Citations)
US3427324A
Cited
US3484445A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-02-27 | 1976-08-28 | 1977-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-02-27 | 1980-08-28 | 1981-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-02-27 | 1984-08-28 | 1985-02-27 | $7700.00 | Window Closed / Lapsed |