US3716335A
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Assaying with change in electron spin resonance spectrum based on chirality
Assignee: SYVA CORP
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Filing: 1971-05-03
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Granted: 1973-02-13
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Expires: 1991-05-03
Abstract
Abstract A method and compounds are provided for determining amounts of energy or chemical reagents in a fluid medium by introducing into the medium a sensor which is a stable nitroxide radical functionality bonded through a methylene group to a central atom bonded to a plurality of functionalities, at least one of which participates in a chemical change, which results in a change of asymmetry about the carbon atom bonded to the methylene group.
Inventors
- 👤 E Ullman
- 👤 R Schneider
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:31
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/28; G01R33/281; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
58 words
A method for detecting in a fluid medium the presence of a chemical or physical agent which induces a chemical reaction other than destruction of a nitroxide free radical or other than the loss or addition of a proton due to change of acidity in said medium which comprises: introducing into said medium a compound of the formula:
Claim 2
Independent Claim
58 words
A method for detecting in a fluid medium the presence of a chemical or physical agent which induces a chemical reaction other than destruction of a nitroxide free radical or other than the loss or addition of a proton due to change of acidity in said medium which comprises: introducing into said medium a compound of the formula:
Claim 3
Dependent Claim
73 words
A method according to claim 1, wherein n is 1 and psi is of the formula: wherein psi is of from 4 to 300 atoms, psi '' is carbon, nitrogen, phosphorous, silicon or sulfur, and X and Y are of from one to 50 atoms, are different and are hydrogen, hydrocarbon, heterofunctionality or substituted hydrocarbon, and Z has a functionality which upon chemical transformation, results in a change in asymmetry about psi ''.
Claim 4
Dependent Claim
11 words
A method according to claim 2, wherein psi '' is carbon.
Claim 5
Dependent Claim
25 words
A method according to claim 2, wherein X and Y are each of from one to 25 atoms and are hydrogen, hydrocarbon or substituted hydrocarbon.
Claim 6
Dependent Claim
76 words
A method according to claim 1, wherein psi is wherein m is 0 to 2, theta is of from four to 20 carbon atoms, L and M are hydrogen or groups of from 0 to 10 atoms other than hydrogen and are different than P and are chosen to provide the necessary asymmetry about the central bond, and P has a functionality which upon chemical transformation results in a change in asymmetry about the double bond.
Claim 7
Dependent Claim
76 words
A method according to claim 1, wherein psi is of the formula: wherein theta 1 2 are each of from four to 20 carbon atoms having from four to six annular members, the pi ''s may be the same or different and are other than hydrogen, at least one pi on theta 2 being alpha to the carbon atom involved in the central bond, and m is 0 or 1, and p is 1 or 2.
Claim 8
Dependent Claim
12 words
A method according to claim 1, wherein said compouNd has the formula:
Claim 9
Dependent Claim
22 words
A method according to claim 7, wherein at least two of X'', Y'' and Z'' are taken together to form a ring.
Claim 10
Dependent Claim
64 words
A method according to claim 7, wherein X'' is hydrogen or a hydrocarbon group of from one to 12 carbon atoms, Y'' is a heterohydrocarbon group of from one to 12 carbon atoms and of from one to six hetero atoms, and Z'' is of from 0 to 20 carbon atoms and from one to six hetero atoms which are oxygen, sulfur or nitrogen.
Claim 11
Dependent Claim
64 words
A method according to claim 7, wherein T1 4 are methyl, X'' is hydrogen or alkyl of from one to six carbon atoms, Y'' is a heterohydrocarbon group of from one to six carbon atoms and from one to four hetero atoms which are nitrogen or oxygen, and Z'' is of from 0 to 20 carbon atoms and from one to six hetero atoms.
Claim 12
Dependent Claim
27 words
A method according to claim 7, wherein the chemical is the zinc cation, T1 4 are methyl, X'' is hydrogen, Y'' is pyridyl and Z'' is carboxy.
Claim 13
Dependent Claim
18 words
A method according to claim 7, wherein Z'' has a carboxy or amino group as its hetero functionality.
Claim 14
Dependent Claim
47 words
A method according to claim 7, wherein X'' and Y'' are different and are hydrogen or hydrocarbon of from one to 12 carbon atoms and Z'' has a heterocyclic functionality and is of not more than 20 carbon atoms and of from one to six hetero atoms.
Claim 15
Dependent Claim
19 words
A method according to claim 13, wherein said heterocyclic functionality is quinoline, pyrazole, rhodanine, quinaldine, tetrazine, imidazoline, or indole.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-02-13 | 1976-08-14 | 1977-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-02-13 | 1980-08-14 | 1981-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-02-13 | 1984-08-14 | 1985-02-13 | $7700.00 | Window Closed / Lapsed |