US3708478A
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A crystalline complex of cephaloridine with an alkane diol
Assignee: Glaxo Laboratories Ltd
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Filing: 1970-07-07
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Granted: 1973-01-02
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Expires: 1990-07-07
Abstract
Abstract A crystalline solvate of cephaloridine with certain alkane diols, e.g., propane -1,3-diol, butane -1,3-diol and butane -2,3diol, a process for the preparation of such solvates and pharmaceutical compositions containing the solvates.
Inventors
- 👤 J Chapman
- 👤 S Staniforth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:41
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/38; C07D501/46
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
50 words
A crystalline complex as defined in claim 1 wherein said alkane diol has the formula: wherein R1 and R2 are independently selected from the group consisting of hydrogen and methyl and n is selected from the group consisting of 1 and, when R1 and R2 are both methyl, 0 and
Claim 2
Dependent Claim
14 words
A crystalline complex as defined in claim 1 wherein said alkane diol is propane-1,3-diol.
Claim 3
Dependent Claim
14 words
A crystalline complex as defined in claim 1 wherein said alkane diol is butane-1,3-diol.
Claim 4
Dependent Claim
14 words
A crystalline complex as defined in claim 1 wherein said alkane diol is butane-2,3-diol.
Claim 5
Dependent Claim
14 words
A crystalline complex as defined in claim 1 wherein said alkane diol is pentane-2,4-diol.
Claim 6
Dependent Claim
68 words
A process for the preparation of a crystalline 1:1 stoichiometric complex of cephaloridine as defined in claim 1 which comprises contacting an addition salt of cephaloridine and an acid having a pKa of 4 or less with the alkane diol in a medium to which is added an inorganic base or an organic base having a pKb of less than 6 and allowing the solvate to crystallize out.
Claim 7
Dependent Claim
15 words
A process as defined in claim 7 wherein said organic base is a tri-(lower alkyl)amine.
Claim 8
Dependent Claim
22 words
A process as defined in claim 7 wherein said inorganic base is an alkali metal or ammonium salt of a weak acid.
Claim 9
Dependent Claim
15 words
A process as defined in claim 7 wherein said acid addition salt is cephaloridine hydronitrate.
References Cited (Backward Citations)
US3352859A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-01-02 | 1976-07-03 | 1977-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-01-02 | 1980-07-03 | 1981-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-01-02 | 1984-07-03 | 1985-01-02 | $7700.00 | Window Closed / Lapsed |