Method of collecting protein substances having biological activity with respect to the nervous system comprising extraction of protein from submaxillary glands
Abstract
Abstract A PROCESS FOR THE RECOVERY OF PROTEIN SUBSTANCES HAVING A BIOLOGICAL ACTIVITY TO PROMOTE THE GROWTH AND DEVELOPMENT OF THE NERVOUS SYSTEM WHICH COMPRISES (A) EXTRACTING THE SUBMAXILLARY GLANDS OF LARGE ANIMALS, I.E. BOVINE, EQUINE AND SWINE, WITH AN AQUEOUS EXTRACTING AGENT SELECTED FROM WATER AND SALINE SOLUTION; (B) ADDING TO THE EXTRACTED SOLUTION SULFOSALICYLIC ACID OR SODIUM SALT TO FORM A SOLUTION HAVING A CONCENTRATION OF 1-2% AND ADJUSTING THE PH OF THE SOLUTION TO 3.0-4.0 AND COLLECTING THE RESULTING PRECIPITATES; (C) DISSOLVING SUCH COLLECTED PRECIPITATES IN AN AQUEOUS SOLUTION; AND (D) SUBJECTING THE AQUEOUS SOLUTION FORMED IN (C) TO FRACTIONAL PRECIPITATION WITH ACETONE OR ALCOHOL IN A CONCENTRATION OF 40-50% AND COLLECTING THE FRACTIONAL PRECIPITATES CONTAINING THE PROTEIN SUBSTANCE. A PROTEIN SUBSTANCE (S) AND A PROTEIN SUBSTANCE (F) CAN BE FURTHER PRODUCED BY ACRINOL PRECIPITATION OF THE REDISSOLVED PROTEIN SUBSTANCE.
Inventors
- 👤 Masaaki Yamamoto
- 👤 Tsuneyuki Nakazawa
Bibliographic Details
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