3-deazapyrimidine nucleosides and method of preparation thereof
Abstract
Abstract NOVEL COMPOUNDS COMPRISING 3-DEAZAPYRIMIDINE NUCLEOSIDES WERE SYNTHESIZED FORM 2,4-SUBSTITUTED PYRIDINE COMPOUNDS BY CONDENSATION WITH 2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSYL BROMIDE, OR THE CHLORIDE THEREOF, AND SUBSEQUIENT MODIFICATION TO YIELD THE DESIRED COMPOUNDS. THESE NOVEL NUCLLEOSIDES HAVE THE STRUCTURE 1-(3-R'',3-R",4-(HO-),5-(HOCH2-)TETRAHYDROFUR-2-YL),2-(O=), 4-R-PYRIDINE WHEREIN R IS A GROUP SELECTED FROM THE CLASS CONSISTING OF HYDROXYL AND AMINE AND R'' AND R" ARE SELECTED FROM THE CLASS CONSISTING OF HYDROGEN AND HYDROXYL, HAVE BEEN FOUND TO INHIBIT CARCINOMA GROWTH IN ANIMAL TISSUE. IN PARTICULAR, 3-DEAZACYTIDINE AND 3-DEAZAURIDINE HAVE BEEN FOUND ESPECIALLY EFFECTIVE IN INHIBITING EHRLICH ASCEITES CARCINOMA AND LEUKEMIA L-1210 GROWTH IN MICE.
Inventors
- 👤 Morris J Robins
- 👤 Bruce L Currie
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-12-05 | 1976-06-05 | 1976-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-12-05 | 1980-06-05 | 1980-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-12-05 | 1984-06-05 | 1984-12-05 | $7700.00 | Window Closed / Lapsed |