Sulphur-containing 1,4-dihydropyridine derivatives

Abstract

Abstract Sulphur-containing 1,4-dihydropyridine derivatives of the formula: D R A W I N G WHEREIN R is hydrogen, saturated or unsaturated, straight, branched or cyclic alkyl of one to six carbon atoms, unsubstituted or substituted by hydroxyl or alkoxy of one to three carbon atoms, or benzyl or phenethyl unsubstituted or substituted in the aryl moiety by one, two or three members selected from the group consisting of one to three alkoxy moieties of one to three carbon atoms, one or two alkyl moieties of one to three carbon atoms and one to two halogen atoms, R'' is straight or branched chain alkyl of one to four carbon atoms, R'''' is straight, branched, cyclic, saturated or unsaturated alkyl of one to six carbon atoms, said alkyl interrupted by one or two oxygen atoms or said alkyl substituted by hydroxyl, R'''''' is aryl substituted by SOnR1, unsubstituted or substituted by one to eight members selected from the group consisting of nitro, amino, acylamino of one to two carbon atoms, hydroxyl, acyloxy of one to two carbon atoms, one or two alkyl moieties of one to four carbon atoms, one or two alkoxy moieties of one to four carbon atoms, and one or two halogen atoms, N IS 0, 1, 2 OR 3, AND R1 is lower alkyl of one to four carbon atoms or phenyl when n is 0, 1 or 2 and R1 is hydrogen when n is 3, ARE USEFUL FOR THEIR CORONARY DILATING EFFECT AND ANTIHYPERTENSIVE EFFECTS. Processes for the production of these compounds are set forth below.

Inventors

• 👤 Friedrich Bossert
• 👤 Wulf Vater

Bibliographic Details