US3681497A
Expired / Lapsed
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Therapeutic methods of employing hydrogen maleate salt of n-(d-6-methyl-8-isoergolenyl)-n{40 ,n{40 -diethyl-carbamide
Assignee: Spofa Vereinigte Pharma Werke
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Filing: 1967-05-25
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Granted: 1972-08-01
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Expires: 1987-05-25
Abstract
Abstract Method of using N-(D-6-methyl-8-isoergolenyl)-N'', N''diethylcarbamide hydrogen maleate in the therapeutic treatment of migraine headache, urticaria, hypertension and allergic conditions, in the last case along or in the form of an enhanced effect when administered together with an anti-histamine.
Inventors
- 👤 Miroslav Semonsky
- 👤 Viktor Zikan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/475
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
57 words
A method of treating a patient for suppressing or mitigating the development of allergic reactions to an allergic stimulus which comprises orally administering to such patient N-(D-6-methyl-8-isoergolenyl)- N'', N''-diethyl-carbamide hydrogen maleate in a dose of 25 mcg two to three times daily, said N-(D-6-methyl-8-isoergolenyl)--N'',N''-diethyl-carbamide hydrogen maleate acting as a specific sertonin antagonist to excessive production of serotonin.
Claim 2
Independent Claim
59 words
A method of treating a patient for suppressing or mitigating the development of urticaria or Quincke''s edema in response to an allergic stimulus which comprises orally administering to such patient N--(D-6-methyl-8-isoergolenyl)-N'',N''-diethyl-carbamide hydrogen maleate in a dose of 35 mcg two to three times daily, said N-(D-6-methyl-8-isoergolenyl)-N'',N''-diethyl-carbamide hydrogen maleate acting as a specific serotonin antagonist to excessive production of sertonin.
Claim 3
Dependent Claim
45 words
Method according to claim 3 wherein said N-(D-6-methyl-8-isoergolenyl)-N'',N''-diethyl-carbamide hydrogen maleate is administered together with 25 mg of another antihistamine, each of said agents being administered two to three times daily, said N-(D-6-methyl-8-isoergolenyl)-N'',N''-diethyl-carbamide hydrogen maleate acting as a specific serotonin antagonist to excessive production of serotonin.
Claim 4
Dependent Claim
20 words
Method according to claim 4 wherein said antihistamine is a member selected from the group consisting of mebrophenhydramine and mebrophenhydrinate.
Claim 5
Independent Claim
40 words
A method of treating hypertension which comprises orally administering to a hypertensive patient N-(D-6-methyl-8-isoergolenyl)-N'',N''-diethyl-carbamide hydrogen maleate in a dosage of about 25 mcg twice daily, said N-(D-6-methyl-8-isoergolenyl)-N'',N''-diethyl-carbamide hydrogen maleate acting as a specific serotonin antagonist to excessive production of serotonin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-08-01 | 1976-01-31 | 1976-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-08-01 | 1980-01-31 | 1980-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-08-01 | 1984-01-31 | 1984-08-01 | $7700.00 | Window Closed / Lapsed |