US3681445A
Expired / Lapsed
US
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Substituted phenyl benzoic acid compounds
Assignee: Merck and Co Inc
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Filing: 1968-01-19
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Granted: 1972-08-01
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Expires: 1988-01-19
Abstract
Abstract The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5(phenyl)benzoic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.
Inventors
- 👤 William V Ruyle
- 👤 Lewis H Sarett
- 👤 Alexander R Matzuk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:59
CPC Classifications
C; C07; C07C; C07C65/00; C07C65/01; C07C65/105; C07C65/21; C07C65/24
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
35 words
A compound of the formula: or a pharmaceutically non-toxic salt wherein X is chloro or fluoro, R is lower alkyl or lower alkoxy; R1 is hydroxy; R2 is hydrogen; R3 is hydrogen or lower alkyl.
Claim 2
Dependent Claim
27 words
A compound of the formula; wherein R is methyl or methoxy; R2 is hydrogen; R3 is hydrogen or methyl; and the pharmaceutically non-toxic acid addition salts thereof.
Claim 3
Dependent Claim
25 words
A compound of claim 3 wherein R is methoxy and is on the 2''-position; R2 is hydrogen; and R3 is hydrogen, thus forming 2-hydroxy-5-(2''-methoxy-4''-fluorophenyl)-benzoic acid.
Claim 4
Dependent Claim
25 words
A compound of claim 3 wherein R is methyl and is on the 2''-position; R2 is hydrogen; and R3 is hydrogen, thus forming 2-hydroxy-5-(2''-methyl-4''-fluorophenyl)-benzoic acid.
Claim 5
Dependent Claim
25 words
A compound of claim 3 wherein R is methyl and is on the 3''-position; R2 is hydrogen; and R3 is hydrogen, thus forming 2-hydroxy-5-(3''-methyl-4''-fluorophenyl)-benzoic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-08-01 | 1976-01-31 | 1976-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-08-01 | 1980-01-31 | 1980-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-08-01 | 1984-01-31 | 1984-08-01 | $7700.00 | Window Closed / Lapsed |