US3678026A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of purifying lower alkyl esters of {60 -l-aspartyl-l-phenylalanine
Assignee: Ajinomoto Co Inc
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Filing: 1970-12-28
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Granted: 1972-07-18
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Expires: 1990-12-28
Abstract
Abstract The lower alkyl esters of Alpha -L-aspartyl-L-phenylalanine, known artificial sweeteners, are separated from the bitter tasting Beta -isomers and other impurities by the low solubility of their adducts with certain aromatic carboxylic acids and phenols in water.
Inventors
- 👤 Yasuo Ariyoshi
- 👤 Tetsuo Yamatani
- 👤 Noboru Uchiyama
- 👤 Sato Naotake
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:50
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06104; C07K5/06113; C07K5/06121; C07K5/0613
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
44 words
A method of preparing the adduct of claim 1 which comprises reacting said ester with said compound in solution in an aqueous medium at pH 2 to 7 until said adduct is precipitated, and separating the precipitated adduct from the remainder of said solution.
Claim 2
Independent Claim
99 words
A method of purifying a lower alkyl ester of Alpha -L-aspartyl-L-phenylalanine which comprises reacting said ester with a precipitant selected from the group consisting of Beta -phenyl-propionic acid, cinnamic acid, o-fluorobenzoic acid, p-hydroxy-benzoic acid, gentisic acid, Beta -resorcylic acid, 5-chlorosalicylic acid, 3,5-dinitrobenzoic acid, 2,4-dichlorophenoxyacetic acid, 2-naphthoic acid, Beta -naphthoxyacetic acid, 2,4-dichlorophenol, 2,5-dichlorophenol and 2,6-dichloro-4-nitrophenol while dissolved in an aqueous medium at pH 2 to 7 until an adduct of said ester with said precipitant is precipitated from said solution, separating the precipitated adduct from said Solution, decomposing the precipitated adduct, and recovering the purified ester from the decomposition product.
References Cited (Backward Citations)
US3492131A
Cited
US3475403A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-07-18 | 1976-01-17 | 1976-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-07-18 | 1980-01-17 | 1980-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-07-18 | 1984-01-17 | 1984-07-18 | $7700.00 | Window Closed / Lapsed |