US3676649A
Expired / Lapsed
US
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Signal analysis and recording
Assignee: Applied Automation Inc
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Filing: 1970-05-08
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Granted: 1972-07-11
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Expires: 1990-05-08
Abstract
Abstract Areas of peaks in a chromatogram or similar signal are computed from measurements of the amplitudes at spaced time intervals. Amplitudes at selected sampling points between the spaced time intervals are calculated. The areas are computed by selectively summing the measured and calculated amplitudes.
Inventors
- 👤 Marvin C Burk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 06:15
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/86; G01N30/8624; Y; Y10; Y10T; Y10T436/00; Y10T436/12
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
230 words
The method of analyzing a fluid mixture which comprises: 1. introducing a sample of a fluid mixture to be analyzed into a chromatographic column, 2. passing carrier fluid through the column to elute the constituents from the column in succession, 3. passing the column effluent through a detector to establish first output signals, the amplitudes of which are indicative of the presence and concentration of the constituents of the fluid mixture, said first output signals constituting a series of peaks, 4. converting said first signals into corresponding second signals in digital form, 5. and measuring the areas under said series of peaks by applying said second signals to a digital computer which is programmed to: a. measure the amplitudes of the peaks periodically at a plurality of equally spaced time intervals and establish a series of third signals representative of the measured amplitudes, b. calculate from the third signals the amplitudes of the peaks at a plurality of times which are spaced from one another by progressively different time intervals which correspond to the progressively different widths of the peaks to be measured, the equally spaced time intervals being shorter than the time intervals at which the ampliTudes of the peaks are calculated, and c. sum the measured third signals and the calculated amplitudes so as to establish final output signals representative of the areas of each of the peaks.
Claim 2
Independent Claim
230 words
The method of analyzing a fluid mixture which comprises: 1. introducing a sample of a fluid mixture to be analyzed into a chromatographic column, 2. passing carrier fluid through the column to elute the constituents from the column in succession, 3. passing the column effluent through a detector to establish first output signals, the amplitudes of which are indicative of the presence and concentration of the constituents of the fluid mixture, said first output signals constituting a series of peaks, 4. converting said first signals into corresponding second signals in digital form, 5. and measuring the areas under said series of peaks by applying said second signals to a digital computer which is programmed to: a. measure the amplitudes of the peaks periodically at a plurality of equally spaced time intervals and establish a series of third signals representative of the measured amplitudes, b. calculate from the third signals the amplitudes of the peaks at a plurality of times which are spaced from one another by progressively different time intervals which correspond to the progressively different widths of the peaks to be measured, the equally spaced time intervals being shorter than the time intervals at which the ampliTudes of the peaks are calculated, and c. sum the measured third signals and the calculated amplitudes so as to establish final output signals representative of the areas of each of the peaks.
Claim 3
Dependent Claim
15 words
passing carrier fluid through the column to elute the constituents from the column in succession,
Claim 4
Dependent Claim
15 words
passing carrier fluid through the column to elute the constituents from the column in succession,
Claim 5
Dependent Claim
62 words
The method of claim 1 wherein each of the times of step (5) (b) is calculated from an equation of the form Tn T(n 1) + PT(n 1) + Q where Tn is the time at which a given calculation is to be made, P and Q are constants, and T(n 1) is the time immediately preceding the given calculated time Tn.
Claim 6
Dependent Claim
117 words
The method of claim 2 wherein the area N1 between times T(n 1) and Tn is calculated from an equation of the form where Tc1 is the end of the equally spaced time interval immediately preceding time Tn 1, Tc2 is the end of the equally spaced time interval immediately following time Tn 1, C2 is the measured amplitude of the peak at time Tc2, Tc3 is the end of the equally spaced time interval immediately preceding time Tn, Tc4 is the end of the equally spaced time interval immediately following time Tn, C4 is the amplitude of the peak at time Tc4, and C3 is the sum of the measured amplitudes between time Tc2 and Tc4.
Claim 7
Dependent Claim
39 words
passing the column effluent through a detector to establish first output signals, the amplitudes of which are indicative of the presence and concentration of the constituents of the fluid mixture, said first output signals constituting a series of peaks,
Claim 8
Dependent Claim
39 words
passing the column effluent through a detector to establish first output signals, the amplitudes of which are indicative of the presence and concentration of the constituents of the fluid mixture, said first output signals constituting a series of peaks,
Claim 9
Dependent Claim
11 words
converting said first signals into corresponding second signals in digital form,
Claim 10
Dependent Claim
11 words
converting said first signals into corresponding second signals in digital form,
Claim 11
Dependent Claim
137 words
and measuring the areas under said series of peaks by applying said second signals to a digital computer which is programmed to: a. measure the amplitudes of the peaks periodically at a plurality of equally spaced time intervals and establish a series of third signals representative of the measured amplitudes, b. calculate from the third signals the amplitudes of the peaks at a plurality of times which are spaced from one another by progressively different time intervals which correspond to the progressively different widths of the peaks to be measured, the equally spaced time intervals being shorter than the time intervals at which the ampliTudes of the peaks are calculated, and c. sum the measured third signals and the calculated amplitudes so as to establish final output signals representative of the areas of each of the peaks.
Claim 12
Dependent Claim
137 words
and measuring the areas under said series of peaks by applying said second signals to a digital computer which is programmed to: a. measure the amplitudes of the peaks periodically at a plurality of equally spaced time intervals and establish a series of third signals representative of the measured amplitudes, b. calculate from the third signals the amplitudes of the peaks at a plurality of times which are spaced from one another by progressively different time intervals which correspond to the progressively different widths of the peaks to be measured, the equally spaced time intervals being shorter than the time intervals at which the ampliTudes of the peaks are calculated, and c. sum the measured third signals and the calculated amplitudes so as to establish final output signals representative of the areas of each of the peaks.
References Cited (Backward Citations)
US3535084A
Cited
US3498106A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-07-11 | 1976-01-10 | 1976-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-07-11 | 1980-01-10 | 1980-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-07-11 | 1984-01-10 | 1984-07-11 | $7700.00 | Window Closed / Lapsed |