Novel process for producing o-anilinophenylaliphatic acid derivatives
Abstract
Abstract WHEREIN A is vinylene, ethylene, etc.; R, R1, R2, and R3 is hydrogen, halogen or lower alkyl, halogen-substituted lower alkyl or lower alkoxy; and R4 is hydroxyl or lower alkoxy, are produced advantageously by contacting carbostyryl derivative of the formula, WHERE A, R, R1, R2 and R3 are as defined above, with compound of the formula, R4H, wherein R4 is as defined above, or contacting benzenecarbonyl derivative of the formula, WHEREIN R, R1, R2 and R3 are as defined above, and R5 is hydrogen or lower alkyl in the presence of an alkali, with triphenyl-alkoxycarbonylmethylphosphonium halide of the formula, WHEREIN R4 is as defined above; R6 is hydrogen or lower alkyl; and X is halogen, and if necessary, further contacting the obtained o-cinnamic acid derivative with hydrogen. O-Anilinophenylaliphatic acid derivatives being excellent in anti-inflammatory activity and extremely low in toxicity and having the formula,
Inventors
- 👤 Hisao Yamamoto
- 👤 Atsuko Hirohashi
- 👤 Takahiro Izumi
- 👤 Masao Koshiba
Bibliographic Details
Claims Analysis
Total Claims: 3References Cited (Backward Citations)
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