US3669837A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for producing 3-(3,4-dimethoxyphenyl)l-alanine by resolution
Assignee: Parke Davis and Co LLC
•
Filing: 1970-03-30
•
Granted: 1972-06-13
•
Expires: 1990-03-30
Abstract
Abstract N-acetyl-3-(3,4-dimethoxyphenyl)alanine is converted by the enzymatic action of an acylase from Aspergillus oryzae to 3-(3,4dimethoxyphenyl)-L-alanine, leaving as an unreacted byproduct Nacetyl-3-(3,4-dimethoxyphenyl)-D-alanine. The process is preferably carried out in the presence of ammonia to adjust the pH to the desired value within the range of 6.0 to 9.0, and in the presence of cobaltous ions in a concentration of 10 4 to 5 X 10 2 M. 3-(3,4-Dimethoxyphenyl)-L-alanine is converted to 3(3,4-dihydroxyphenyl)-L-alanine by cleavage of the ether groups.
Inventors
- 👤 Robert F Parcell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 18:14
CPC Classifications
C; C12; C12P; C12P13/00; C12P13/04; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/913; Y10S435/918
Claims Analysis
Total Claims: 0
No claims parsed yet. Click Sync Now above to re-index claims from Google Patents.
References Cited (Backward Citations)
US3243356A
Cited
US3290225A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-06-13 | 1975-12-13 | 1976-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-06-13 | 1979-12-13 | 1980-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-06-13 | 1983-12-13 | 1984-06-13 | $7700.00 | Window Closed / Lapsed |