Esters and amides of (diazomethyl) phosphonic acid

Abstract

Abstract A method for the preparation of (cis-1,2-epoxypropyl)-phosphoric acid diesters and diamides which comprises treating the corresponding diester or diamide of (diazomethyl)-phosphonic acid with acetaldehyde or, alternatively, treating a mixture of an appropriate diester or diamide of formylphosphonic acid with diazoethane. The (cis-1,2-epoxypropyl) acid diesters and diamides thus obtained have utility as intermediates inasmuch as they may be converted to the pharmacologically active (cis-1,2epoxypropyl)phosphonic acid and to the salts thereof which inhibit the growth of gram-positive and gram-negative pathogenic bacteria.

Inventors

• 👤 Raymond A Firestone

Bibliographic Details