Diacyl penicillins and methods for their production
Abstract
Abstract NOVEL DIACYL PENICILLINS OF THE FORMULA 2-(R-OOC-),3,3-DI(CH3-),6-((3-(R1,R2-PHENYL),5-CH3- ISOXAZOL-4-YL)-CO-N(-CO-CH2-C6H5)-)PENAM WHEREIN R IS A PROTECTIVE GROUP FOR THE CARBOXYL GROUP, AND R1 AND R2 ARE INDIVIDUALLY HYDROGEN OR HALOGEN, ARE PRODUCED BY REACTING A BENZL PENICILLIN ESTER OF THE FORMULA 2-(R-OOC-),3,3-DI(CH3-),6-(PHENYL-CH2-CO-NH-)PENAM WHEREIN R IS AS DEFINED ABOVE, WITH A CHLORINATING AGENT IN THE PRESENCE OF A TERTIARY ORGANIC BASE TO OBTAIN AN IMIDE CHLORIDE GROUP-INCORPORATED COMPOUND OF THE FORMULA 2-(R-OOC-),3,3-DI(CH3-),6-(PHENYL-CH2-C(-CL)=N-)PENAM AND THEN REACTING THE COMPOUND OF THE LAST-NAMED FORMULA WITH AN ISOXAZOL CARBOXYLATE OF THE FORMULA 3-(R1,R2-PHENYL),4-(M-OOC-),5-CH3-ISOXAZOLE WHEREIN M IS A METAL ATOM, AND R1 AND R2 ARE AS DEFINED ABOVE.
Inventors
- 👤 Jinnosuke Abe
- 👤 Tetsuo Watanabe
- 👤 Teruo Take
- 👤 Kentaro Fujimoto
- 👤 Tadashiro Fujii
- 👤 Kazunari Takemura
- 👤 Kazuyoshi Nishii
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-04-25 | 1975-10-25 | 1976-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-04-25 | 1979-10-25 | 1980-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-04-25 | 1983-10-25 | 1984-04-25 | $7700.00 | Window Closed / Lapsed |