17-acyloxysteroids and their manufacture

Abstract

Abstract WHERE R3 IS CHLORINE, BROMIDE, ALKANOYLOXY, AN ALKANESULPHONYOXY-OR ARENESULPHONYLLOXY-GROUP AND R1, A AND THE SYMBOL = ARE AS HEREINBEFORE DEFINED, AND THEREAFTER (A) REPLACING THE GROUP R3 BY HYDROGEN, THEN CONVERTING THE 17A-HYDROXYL GROUP INTO THE GROUP O.COR2 AND FINALLY REDUCING THE 11B-NITRATE GROUP TO AN 11BHYDROXYL GROUP; OR (B) CONVERTING THE 17A-HYDROXYL GROUP INTO THE GROUP O.COR*2, THEN REDUCING THE 11B-NITRATE GROUP TO AN 11B-HYDROXYL GROUP AND FINALLY REPLACING THE GROUP R*3 BY HYDROGEN; OR (C) CONVERTING THE 17A-HYDROXYL GROUP INTO THE GROUP O.COR2, THEN REPLACING THE GROUP R3 BY HYDROGEN AND FINALLY REDUCING THE 11B-NITRATE GROUP TO AN 11BHYDROXYL GROUP. PHENANTHRENE AND ITS 5,6,9,10-DEHYDRO DERIVATIVE (III) 9-R1-1,2,3,4,4A,4B,5,6,7,9,10,10A-DODECAHYDRO 1,2-(-CH2-A-C(-OH)(-CO-CH2-R3),2-(CH3-),4(O2N-),7-(O=), AND ITS 5,6 DEHYDRO DERIVATIVE (II) 9-R1-1,2,3,4,4A,4B,5,6,7,10A-DODECAHYDROPHENANTHRENE 1,2-(-CH2-A-C(-OH)(-CO-CH2-R3)-),2-(CH3-),4-(HO-),7-(O=), THE INVENTION CONCERNS NOVEL STEROIDS HAVING VALUABLE PROPERTIES AS ANTI-INFLAMMATORY AGENTS IN VETERINARY AND HUMAN MEDICINE. THE NEW STEROIDS ARE 17A-ACYLOXY-B-HYDROXY PROGESTERONES AND THEIR $1, $6, $1,6, 21-HALO-$1 AND 21-HALO-$1,6 DERIVATIVES. PROCESSES FOR THEIR PREPARATION INCLUDE THE CONVERSION OF A COMPOUND OF THE GENERAL FORMULA II INTO THE CORRESPONDING 11B-NITRATE ESTER III,

Inventors

• 👤 Peter Oxley
• 👤 John Rosindale Housley

Bibliographic Details