US3639211A
Expired / Lapsed
US
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Process for the preparation of creatine phosphate
Assignee: Roche Diagnostics GmbH
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Filing: 1968-11-19
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Granted: 1972-02-01
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Expires: 1988-11-19
Abstract
Abstract Process for preparing creatine phosphate comprising incubating in an alkaline medium creatine and 3-phosphoglyceric acid with an aqueous muscle extract in the presence of a catalytic amount of adenosine triphosphate, heating the resulting mixture for a short period of time to a temperature of 70* to 100* C. and recovering the creatine phosphate which is thereby formed.
Inventors
- 👤 Klaus Beaucamp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 01:01
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/22; C07F9/222; A; A23; A23J; A23J3/00; A23J3/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
19 words
Process according to claim 1 which comprises utilizing 1.1 to 1.5 equivalents of creatine per equivalent of 3-phosphoglyceric acid.
Claim 2
Dependent Claim
23 words
Process according to claim 1 which comprises utilizing said adenosine triphosphate disodium salt and creatine in a molar ratio of 1:60 to 1:100.
Claim 3
Dependent Claim
17 words
Process according to claim which comprises conducting said incubation at a pH of from 7.0 to 11.
Claim 4
Dependent Claim
17 words
Process according to claim 1 which comprises conducting said incubation at a pH of 8.0 to 9.0.
Claim 5
Dependent Claim
21 words
Process according to claim 1 which comprises conducting said incubation at a temperature ranging from room temperature to about 45* C.
Claim 6
Dependent Claim
20 words
Process according to claim 1 which comprises conducting said incubation at a room temperature of from 32* to 40* C.
Claim 7
Dependent Claim
16 words
Process according to claim 1 which comprises utilizing as said muscle extract an aqueous veal extract.
Claim 8
Dependent Claim
16 words
Process according to claim 1 which comprises utilizing as said muscle extract an aqueous rabbit extract.
Claim 9
Dependent Claim
61 words
Process according to claim 9 which comprises preparing said aqueous rabbit muscle extract by extracting homogenized rabbit muscle with water, heating the aqueous extract to a temperature of from about 50* to 60* C, separating off any precipitated protein, introducing ammonium sulfate into the supernatant liquid to provide a 3 M concentration, separating off any precipitated protein and dialyzing the same.
Claim 10
Dependent Claim
32 words
Process according to claim 1 which comprises adjusting the concentration of magnesium and potassium ions in said aqueous muscle extract to a value of 1-2 X 10 3for each of said ions.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-01-31 | 1975-08-02 | 1976-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-01-31 | 1979-08-02 | 1980-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-01-31 | 1983-08-02 | 1984-02-01 | $7700.00 | Window Closed / Lapsed |