2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives
Abstract
Abstract NEW COMPOUNDS, 2-(6''-METHOXYNAPHTH-2''-YL)PROPYLENE OXIDE, 2-N6''-METHOXYNAPHTH-2''-YL)PROPIONALDOXIME, 2-HYDROXY-2-(6''-METHOXYNAPHTH-2''YL)PROPIONITRILE, 2-(6''METHOXYNAPHTH-2''-YL)ACRYLONITRILE, 2-(6''-METHOXYNAPHTH-2''YL)ACRYLIC ACID, THE CORRESPONDING 5''-HALO COMPOUNDS AND 2 - (5''-HALO-6''-METHOXYNAPHTH-2''YL)PROPIONALDEHYDE ARE USEFUL INTERMEDIATES IN PRODUCING 2-(6''-METHOXYNAPHTH2''-YL)PROPIONIC ACID AND THE CORRESPONDING 5''-HALO ACIDS FROM 6-METHOXY-2-CETYLNAPHTHALENE AND THE CORRESPONDING 5-HALO COMPOUNDS. THE 2-PROPIONIC ACIDS ARE ANTIINFLAMMATORY, ANALESIC, ANTI-PYRETIC AND ANTI-PRURITIC AGENTS. THE 2-PROPIONALDEHYDES, OBTAINED FROM THE 2-ACETYL COMPOUNDS BY WAY OF THE 2-PROPYLENE OXIDE, CAN BE CONVERTED DIRECTLY TO THE 2-PROPIONIC ACIDS BY WAY OF THE 2-PROPIONALDOXIMES AND THE 2-PROPIONITRILES OR MORE DIRECTLY BY JONES OXIDATION. ALTERNATIVELY THE 2-ACRYLONITRILES, OBTAINED FROM THE 2-ACETYL COMPOUNDS BY WAY OF THE 2-HYDROXY-2-PROPIONITRILE, CAN BE CONVERTED TO THE 2PROPIONIC ACID BY WAY OF THE 2-ACRYLIC ACID OR 2-PROPIONITRILE.
Inventors
- 👤 Francisco S Alvarez
Bibliographic Details
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