Preparation of heterocycloimidazoles
Abstract
Abstract 1,3-DIMETHYL - 1,2,3,4 - TETRAHYDROPYRIDO(2,1-F)PURINE2,4-DIONE IS PREPARED BY EXTRUDING SULFUR MONOXIDE FROM 1,3 - DIMETHYL - 1,2,3,4 - TETRAHYDROPYRIDO(1,2-B)6H- PYRIMIDO(4,5-E)(1,2,4)THIADIAZINE-2,4,5-TRIONE, WHICH IS PREPARED BY TREATING 1,3-DEIMETHYL-6-(2-PYRIDYLAMINO)URACIL WITH THIONYL CHLORIDE. THE EXTRUSION PROVIDES A GENERAL ROUTE TO VARIOUS IMIDAZOLES, ESPECIALLY HETEROCYCLOIMIDAZOLES, THROUGH INTERMEDIATE 2H-1,2,4-THIADIAZINE-1-OXIDES WHICH CAN BE PREPARED FROM N-VINYLAMIDINES. AN ALTERNATIVE ROUTE IS HEATING 1,3-DIMETHYL-5-HALO-6-(2-PYRIDYLAMINO)URACIL. NOVEL 1,3-DIMETHYL-1,2,3,4-TETRAHYDROHETEROCYCLO(X,Y-F)PURINE-2,4-DIONES ARE USEFUL FOR A VARIETY OF BIOLOGICAL AND CHEMOTHERAPEUTIC PURPOSES.
Inventors
- 👤 Irving M Goldman
Bibliographic Details
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