Polyvalent bovine vaccines and methods of making and using same
Abstract
Abstract A POLYVALENT VACCINE EFFECTIVE IN IMMUNIZATION OF BOVINES AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS (IBR), BOVINE VIRAL DIARRHEA VIRUS (BVD) AND PARAINFLUENZA-3 VIRUS (PI-O) IS COMPOSED OF A SUPENSION, IN A VEHICLE SUCH AS A SQUEOUS SOLUTION OF FORMALDEHYDE SUITABLE FOR PARENTERAL INJECTION OF THE THREE VIRUSES IN KILLED FORM. THE THREE VIRUSES ARE SEPARATELY PROPAGANTED AND SEPARTELY SUSPENDED IN AQUEOUS SOLUTIONS CONTAINING 0.4% BY VOLUME FORMALIN, AND THE RESPECTIVE SUSPENSIONS ARE MAINTAINED AT A TEMPERATURE OF ABOUT 4*C. FOR ONE WEEK. PORTIONS, FOR EXAMPLE EQUAL PORTIONS, OF THE THREE SUPENSIONS ARE COMBINED TO PRODUCE A POLYVALENT VACCINE. AND EQUAL VOLUME OF AN AQUEOUS SOLUTION CONTAINING FROM ONE TO FIVE PERCENT WEIGHT/VOLUME OF A SOLUBLE ALGINATE, SUCH AS SODIUM ALGINATE, HAVING CERTAIN SPECIFIED PROPERTIES MAY BE ADDED TO THE VACCINE AS A ADJUVANT TO ENHANCE ITS EFFECTIVENESS. SUCH POLYVALENT VACCINES ARE ADAPTED FOR PARENTERAL ADMINISTRATION IN THE VACCINATION OF BOVINES.
Inventors
- 👤 Isaac L Shechmeister
- 👤 Joseph R Kolar Jr
- 👤 William G Kamlade Jr
Bibliographic Details
Claims Analysis
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