Derivatives of the 2-(lower alkyl)-3-(lower alkyl)-4-phenyl-3- or 4-cyclohexenecarboxylic acids

Abstract

Abstract COMPOUNDS OF THE GENERAL FORMULA 1-(R''-OOC-),2-R",3-R"'',4-PHENYL-CYCLOHEX-3(OR 4)-ENE ARE DISCLOSED WHEREIN R" AND R''" ARE SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL OF UP TO 3 CARBON ATOMS; AND R'' IS SELECTED FROM THE GROUP CONSISTING OF ALKYL OF FROM 9 TO 20 CARBON ATOMS, ALKENYL OF UP TO 20 CARBON ATOMS, MONOHYDROXY LOWER ALKYL, DIHYDROXY LOWER ALKYL, ADAMANIYL, ADAMANTYL LOWER ALKYL, PHENYL, PHENYL LOWER ALKYL, DIPHENYL LOWER ALKYL, CYCLOALKYL, CYCLOALKYL LOWER ALKYL, CARBO LOWER ALKOXY LOWER ALKYL, LOWER ALKOXY LOWER ALKYL, FURYL, FURYL LOWER ALKYL, CARBO LOWER ALKOXY PHENYL, POPERIDYL, PIPERIDYL LOWER ALKYL, PHENYL-CYCLOHEXENYLMETHYL IN WHICH THE CYCLOHEXENYL GROUP CONTAINS SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL OF UP TO 3 CARBON ATOMS AND THE DOTTED LINES REPRESENT A DOUBLE BOND AT EITHER THE 3-OR THE 4-POSITION. THESE COMPOUNDS EXHIBIT ESTROGENIC PROPERTIES AND WHEN GIVEN IN A SINGLE SUBCUTANEOUS DOES HAVE LONL ACTING EFFECTS IN THE SUPPRESSION OF ANIMAL REPRODUCTION.

Inventors

• 👤 George Karmas

Bibliographic Details