US3627698A
Expired / Lapsed
US
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Hydroperoxide diagnostic agents containing a chromogen indicator
Assignee: Roche Diagnostics GmbH
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Filing: 1970-03-20
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Granted: 1971-12-14
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Expires: 1990-03-20
Abstract
Abstract D R A W I N G
Inventors
- 👤 Hans-Georg Rey
- 👤 Hans Wielinger
- 👤 Peter Rieckmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:34
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; C12Q1/54; C12Q2326/00; C12Q2326/30; Y; Y10; Y10S; Y10S435/00; Y10S435/803; Y10T; Y10T436/00; Y10T436/20; Y10T436/206664
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
47 words
Diagnostic agent according to claim 1 for use in the determination of hydroperoxide or a substance which reacts with the liberation of hydrogen peroxide comprising a member selected from the group consisting of peroxidase and a peroxidatively active substance and a chromogen as defined in claim 1.
Claim 2
Dependent Claim
39 words
Diagnostic agent according to claim 1 for use in the determination of peroxidatively active substances comprising a member selected from the group consisting of hydrogen peroxide and substances forming hydrogen peroxide and a chromogen as defined in claim 1.
Claim 3
Dependent Claim
31 words
Diagnostic agent as claimed in claim 1 wherein one, and only one, of the X groups in the formula is oxygen or a carbon atom substituted with two lower alkyl groups.
Claim 4
Dependent Claim
28 words
Diagnostic agent as claimed in claim 1 wherein neither of the X groups in the formula is oxygen or a carbon atom substituted with two lower alkyl groups.
Claim 5
Dependent Claim
18 words
Diagnostic agent according to claim 1 in the form of a test paper impregnated with said diagnostic agent.
Claim 6
Dependent Claim
18 words
Diagnostic agent according to claim 1 in the form of a test film impregnated with said diagnostic agent.
Claim 7
Dependent Claim
13 words
Diagnostic agent according to claim 1 in the form of a solution thereof.
Claim 8
Dependent Claim
107 words
Diagnostic agent according to claim 1 additionally containing a compound having the formula: wherein Ar is a member selected from the group consisting of benzene and naphthalene nuclei, V is a member selected from the group consisting of hydroxyl and amino, v'' is a member selected from the group consisting of hydrogen, hydroxy, Amino, alkylated amino and arylated amino, W is a member selected from the group consisting of amino, carboxy, alkyl, alkoxy, aryl and sulfonic acid groups and W'' is a member selected from the group consisting of hydrogen, amino, carboxy, alkyl, alkoxy, aryl, sulfonic acid groups and alkali metal carboxylate or sulfonate groups, as modifier.
Claim 9
Dependent Claim
107 words
Diagnostic agent according to claim 2 additionally containing a compound having the formula: wherein Ar is a member selected from the group consisting of benzene and naphthalene nuclei, V is a member selected from the group consisting of hydroxyl and amino, V'' is a member selected from the group consisting of hydrogen, hydroxy, amino, alkylated amino and arylated amino, W is a member selected from the group consisting of amino, carboxy, alkyl, aryl, alkoxy and sulfonic acid groups and W'' is a member selected from the group consisting of hydrogen, amino, carboxy, alkyl alkoxy, aryl, sulfonic acid groups and alkali metal carboxylate or sulfonate groups, as modifier.
Claim 10
Dependent Claim
107 words
Diagnostic agent according to claim 3 additionally containing a compound having the formula: wherein Ar is a member selected from the group consisting of benzene and naphthalene nuclei, V is a member selected from the group consisting of hydroxyl and amino, V'' is a member selected from the group consisting of hydrogen, hydroxy, amino, alkylated amino and arylated amino, W is a member selected from the group consisting of amino, carboxy, alkyl, alkoxy, aryl and sulfonic acid groups and W'' is a member selected from the group consisting of hydrogen, amino, carboxy, alkyl, alkoxy, aryl, sulfonic acid groups and alkali metal carboxylate or sulfonate groups, as modifier.
Claim 11
Dependent Claim
13 words
Diagnostic agent according to claim 1 wherein said chromogen (I) is 2,2''-azino-di-(3-ethyl-benzthiazolone-6-sulfonic acid).
Claim 12
Dependent Claim
12 words
Diagnostic agent according to claim 1 wherein said chromogen (I) is 2,2''-azino-di-(1-ethyl-quinoline-6-sulfonic-acid).
Claim 13
Dependent Claim
19 words
Diagnostic agent according to claim 9 wherein said chromogen (I) is 2,2''-azino-di-(1-ethyl-quinoline-6-sulfonic acid) and said modifier is o-amino-phenol-p-sulfonic acid.
Claim 14
Dependent Claim
19 words
Diagnostic agent according to claim 9 wherein said chromogen (I) is 2,2''-azino-di-(3-ethyl-benzthiazolone-6-sulfonic acid) and said modifier is p-amino-salicylic acid.
Claim 15
Dependent Claim
39 words
Diagnostic agent according to claim 9 wherein said modifier is a member selected from the group consisting of o-amino-phenol-p-sulfonic acid, (1-amino-naphthol-8)-2, 4-disulfonic acid, (7-amino-naphthol-1)-3,6-disodium sulfonate, naphthyl-1-amino-6-sulfonic acid, naphthyl-1-amino-8-sulfonic acid, p-aminosalicylic acid, o-amino-phenol, m-amino-phenol, p-phenetidene, 2-hydroxy-4-amino-4-methoxy-diphenylamine, and Alpha -naphthol-2-sulfonic acid.
Claim 16
Dependent Claim
64 words
Process for the analytical determination of hydroperoxide, a substance which reacts with the liberation of hydroperoxide, peroxidase and a peroxidate-active substance which comprises contacting a liquid containing the substance of interest with a reagent comprising a diagnostic agent according to claim 1, producing a color with respect to said liquid as visual evidence of the presence of said substance of interest in said liquid.
Claim 17
Dependent Claim
64 words
Process for the analytical determination of hydroperoxide, a substance which reacts with the liberation of hydroperoxide, peroxidase and a peroxidate-active substance which comprises contacting a liquid containing the substance of interest with a reagent comprising a diagnostic agent according to claim 9, producing a color with respect to said liquid as visual evidence of the presence of said substance of interest in said liquid.
References Cited (Backward Citations)
US3183173A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-12-13 | 1975-06-14 | 1975-12-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-12-13 | 1979-06-14 | 1979-12-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-12-13 | 1983-06-14 | 1983-12-14 | $7700.00 | Window Closed / Lapsed |