US3622276A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chromatography system
Assignee: Revvity Health Sciences Inc
•
Filing: 1969-05-06
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Granted: 1971-11-23
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Expires: 1989-05-06
Abstract
Abstract Apparatus and method for particular use in thin layer chromatography (TLC). The chromatogram is developed on the inside of a tubular conduit internally coated with the combination of an adsorbent and a reactant or a catalyst capable of decomposing adsorbed compounds to gaseous products at elevated temperature. For the analysis, carrier gas is passed through the conduit and heat is applied to a selected zone. The zone is then moved along the conduit to decompose chromatographically resolved compounds, thereby changing the composition of the carrier gas stream. This composition change is determined as a measure of the composition of the chromatographically resolved mixture.
Inventors
- 👤 Eero O A Haahti
- 👤 Ilmari P Jaakonmaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 12:15
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/50; G01N30/90; G01N30/94; G01N30/95; Y; Y10; Y10T; Y10T436/00; Y10T436/21
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
16 words
Apparatus of claim 1 wherein said substance and said adsorbent are internally coated on said conduit.
Claim 2
Dependent Claim
12 words
Apparatus of claim 1 wherein said substance is a metal oxide oxidant.
Claim 3
Dependent Claim
102 words
Apparatus for analyzing a chromatographically developed mixture, comprising: a. means for flowing a carrier gas through an elongated tubular conduit containing, in combination, a chromatographically active adsorbent and a substance capable of decomposing adsorbed compounds to gasiform products at elevated temperature, b. means for heating a zone of said conduit to said elevated temperature, c. means for advancing said heating means longitudinally of said elongated tubular conduit to decompose progressive increments of said chromatographically developed mixture to gasiform products, d. and means for determining the resulting change in composition of said carrier gas as a measure of the composition of said mixture.
Claim 4
Dependent Claim
12 words
Apparatus of claim 4 wherein said carrier gas is an inert gas.
Claim 5
Dependent Claim
10 words
Apparatus of claim 5 wherein said carrier gas is helium.
Claim 6
Dependent Claim
14 words
Apparatus of claim 4 wherein said tubular conduit is internally coated with said combination.
Claim 7
Dependent Claim
13 words
Apparatus of claim 4 including means for recording said carrier gas composition changes.
Claim 8
Dependent Claim
12 words
Apparatus of claim 4 wherein said adsorbent is silica gel or alumina.
Claim 9
Dependent Claim
12 words
Apparatus of claim 4 wherein said substance is a metal oxide oxidant.
Claim 10
Dependent Claim
11 words
Apparatus of claim 10 wherein said metal oxide is cupric oxide.
Claim 11
Dependent Claim
11 words
Apparatus of claim 4 wherein said substance is a cracking catalyst.
Claim 12
Dependent Claim
15 words
Apparatus of claim 4 wherein said carrier gas composition change determining means is a catharometer.
Claim 13
Dependent Claim
17 words
Apparatus of claim 4 wherein said carrier gas composition change determining means is a radioactivity measuring device.
Claim 14
Dependent Claim
28 words
Apparatus of claim 4 including means for removing water vapor from said carrier gas downstream of said conduit and prior to said carrier gas composition change determining means.
Claim 15
Dependent Claim
22 words
Apparatus of claim 4 including supplemental oxidation means downstream of said conduit and prior to said carrier gas composition change determining means.
Claim 16
Independent Claim
95 words
A method for analyzing a chromatographically developed mixture, comprising: a. flowing a carrier gas through an elongated tubular conduit containing, in combination, a chromatographically active adsorbent and a substance capable of decomposing adsorbed compounds to gasiform products at elevated temperature, b. heating a zone of said conduit to said elevated temperature, c. advancing said heating means longitudinally of said elongated tubular conduit to decompose progressive increments of a chromatographically developed mixture to gasiform products, d. and determining the resulting change in composition of said carrier gas as a measure of the composition of said mixture.
Claim 17
Dependent Claim
14 words
Method of claim 17 wherein said chromatographically developed mixture is a thin layer chromatogram.
Claim 18
Dependent Claim
17 words
Method of claim 17 wherein said adVancement is in a direction opposite the direction of chromatographic development.
Claim 19
Dependent Claim
14 words
Method of claim 17 wherein said tubular conduit is internally coated with said combination.
Claim 20
Dependent Claim
10 words
Method of claim 18 wherein said carrier gas is helium.
Claim 21
Dependent Claim
12 words
Method of claim 17 wherein said adsorbent is silica gel or alumina.
Claim 22
Dependent Claim
12 words
Method of claim 17 wherein said substance is a metal oxide oxidant.
Claim 23
Dependent Claim
11 words
Method of claim 23 wherein said metal oxide is cupric oxide.
Claim 24
Dependent Claim
17 words
Method of claim 17 wherein said substance is a cracking catalyst and said carrier gas comprises hydrogen.
Claim 25
Dependent Claim
35 words
A thin layer chromatography tube comprising an elongated tubular conduit having an internal surface comprising, in combination, a chromatographically active adsorbent and a substance capable of decomposing adsorbed compounds to gasiform products at elevated temperature.
Claim 26
Dependent Claim
11 words
Tube of claim 26 wherein said surface is an internal coating.
Claim 27
Dependent Claim
10 words
Tube of claim 26 wherein said adsorbent is silica gel.
Claim 28
Dependent Claim
9 words
Tube of claim 26 wherein said adsorbent is alumina.
Claim 29
Dependent Claim
11 words
Tube of claim 26 wherein said adsorbent is a molecular sieve.
Claim 30
Dependent Claim
12 words
Tube of claim 26 wherein said substance is a metal oxide oxidant.
Claim 31
Dependent Claim
11 words
Tube of claim 26 wherein said metal oxide is cupric oxide.
Claim 32
Dependent Claim
11 words
Tube of claim 26 wherein said substance is a cracking catalyst.
Claim 33
Dependent Claim
18 words
Tube of claim 26 wherein said conduit has an outside diameter between about one-sixteenth and about one-half inches.
Claim 34
Dependent Claim
17 words
Tube of claim 26 wherein said conduit is necked down to reduced dimension near one end thereof.
References Cited (Backward Citations)
US3419359A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-11-22 | 1975-05-24 | 1975-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-11-22 | 1979-05-24 | 1979-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-11-22 | 1983-05-24 | 1983-11-23 | $7700.00 | Window Closed / Lapsed |