Perhydro-5-phenyl-cycloalkapolyene-1,4-oxazepines and their preparations

Abstract

Abstract PERHYDRO - 5 - PHENYL - CYCLOALKAPOLYLENE - 4,1-OXAZEPINES OF THE FORMULA XXII: 3-R2=,R6=,4-R1,5,6-(-CH2-(CH2)N-CH2-),7-(R1,R4,R5-BENZENE- TETRAYL)-HEXAHYDRO-1,4-OXAZEPINE (XXIII) WHEREIN N HAS A VALVUE FROM 1 TO 4, INCLUSIVE; WHEREIN R1 IS HYDROGEN, ALKYL FROM 1 TO 16 CARBON ATOMS, INCLUSIVE, PHENYLALKYL, HETEROCYCLICAMINOALKYL, ALKYLAMINOALKY, DIALKYLAMINOALKY, ALKANOYL FROM 1 TO 16 CARBON ATOMS, INCLUSIVE, BENZOYL, PHENYLACETYL, -(CH2)3-CO-(1,4-PHENYLENE)-F OR -SO2-(1,4-PHENYLENE)-NH2 WHEREIN R2 IS H-C--H OR =O WHEREIN R3, R4 AND R5 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HYDROXY, HALOGEN, LOWER ALKYL, LOWER ALKOXY, LOWER ALKANOYLOXY AND CF3; AND WHEREIN R6 IS HYDROGEN OR H3C-C--CH3 INCLUDING ACID ADDITION SALTS, QUATERNARY AMMONIUM SALTS, THE N-OXIDES AND ACID ADDITION SALTS THEREOF ARE PREPARED. THE COMPOUNDS OF THE FORMULA ABOVE, WHEREIN R2 IS H-C--H STIMULATE THE CENTRAL NERVOUS SYSTEM AND CAN BE USED ORALLY OR PARENTERALLY IN THE TREATMENT OF RESPIRATORY DIFFICULTIES AND GERIATRICS IN FARM OR PET ANIMALS. THE COMPOUNDS OF THE ABOVE FORMULA WHEREIN R2 IS =O ARE INTERMEDIATES.

Inventors

• 👤 Jacob Szmuszkovicz

Bibliographic Details